Dyduch Grzegorz, Tyrak Katarzyna E, Glajcar Anna, Szpor Joanna, Okoń Krzysztof
Chair of Pathomorphology, Jagiellonian University Medical College, Krakow, Poland.
II Chair of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland.
Postepy Dermatol Alergol. 2017 Jun;34(3):233-239. doi: 10.5114/ada.2017.67845. Epub 2017 May 29.
Dendritic cells are crucial for cutaneous immune response. Their role in melanoma progression is however a matter of controversy.
The number of dendritic cells within epidermis and in peri- and intratumoral location was analyzed using CD207 immunostain in 17 cases of in situ and 25 case of invasive melanoma.
Average peritumoral CD207+ cells count was 22.88 for all cases, 17.94 for lesions and 26.24 for invasive cases. Average epidermal CD207+ cells count was 164.47 for all cases, 183.00 for lesions and 150.78 - for invasive cases. In case of invasive melanomas, peritumoral CD207+ cells count was positively correlated with Breslow stage ( = 0.59) mitotic activity within the tumor ( = 0.62). Invasive cases with regression showed higher intratumoral and epidermal CD207+ cells count than the ones without (275.00 vs. 95.32 and 173.20 vs. 148.35) but lower peritumoral CD207+ cells count (17.60 vs. 27.26). Invasive cases with ulceration showed higher intratumoral and peritumoral CD207+ cells count than the ones without ulceration (220.08 vs. 55.67 and 44.17 vs. 9.69).
CD207+ cells play a role in both progression and regression of melanoma but their exact role needs further studies.
树突状细胞对皮肤免疫反应至关重要。然而，它们在黑色素瘤进展中的作用仍存在争议。
使用CD207免疫染色分析了17例原位黑色素瘤和25例浸润性黑色素瘤中表皮以及肿瘤周围和肿瘤内的树突状细胞数量。
所有病例的肿瘤周围平均CD207 +细胞计数为22.88，原位病变为17.94，浸润性病例为26.24。所有病例的表皮平均CD207 +细胞计数为164.47，原位病变为183.00，浸润性病例为150.78。在浸润性黑色素瘤中，肿瘤周围CD207 +细胞计数与Breslow分期呈正相关（ = 0.59），与肿瘤内的有丝分裂活性呈正相关（ = 0.62）。有消退的浸润性病例的肿瘤内和表皮CD207 +细胞计数高于无消退的病例（分别为275.00对95.32和173.20对148.35），但肿瘤周围CD207 +细胞计数较低（17.60对27.26）。有溃疡的浸润性病例的肿瘤内和肿瘤周围CD207 +细胞计数高于无溃疡的病例（分别为220.08对55.67和44.17对9.69）。
CD207 +细胞在黑色素瘤的进展和消退中均起作用，但其确切作用需要进一步研究。
