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Down-regulation of long non-coding RNA AFAP1-AS1 inhibits tumor cell growth and invasion in lung adenocarcinoma.长链非编码RNA AFAP1-AS1的下调抑制肺腺癌肿瘤细胞的生长和侵袭。
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2
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AFAP1-AS1, a long noncoding RNA upregulated in lung cancer and promotes invasion and metastasis.AFAP1-AS1，一种在肺癌中上调的长链非编码RNA，可促进侵袭和转移。
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本文引用的文献

1
AFAP1-AS1, a long noncoding RNA upregulated in lung cancer and promotes invasion and metastasis.AFAP1-AS1，一种在肺癌中上调的长链非编码RNA，可促进侵袭和转移。
Tumour Biol. 2016 Jan;37(1):729-37. doi: 10.1007/s13277-015-3860-x. Epub 2015 Aug 6.
2
High expression of AFAP1-AS1 is associated with poor survival and short-term recurrence in pancreatic ductal adenocarcinoma.AFAP1-AS1的高表达与胰腺导管腺癌的不良生存和短期复发相关。
J Transl Med. 2015 Apr 30;13:137. doi: 10.1186/s12967-015-0490-4.
3
Long noncoding RNA MALAT1 promotes brain metastasis by inducing epithelial-mesenchymal transition in lung cancer.长链非编码RNA MALAT1通过诱导肺癌上皮-间质转化促进脑转移。
J Neurooncol. 2015 Jan;121(1):101-8. doi: 10.1007/s11060-014-1613-0. Epub 2014 Sep 14.
4
miR-340 inhibits tumor cell proliferation and induces apoptosis by targeting multiple negative regulators of p27 in non-small cell lung cancer.微小RNA-340通过靶向非小细胞肺癌中p27的多个负调节因子来抑制肿瘤细胞增殖并诱导细胞凋亡。
Oncogene. 2015 Jun;34(25):3240-50. doi: 10.1038/onc.2014.267. Epub 2014 Aug 25.
5
Long noncoding RNA expression profiles of lung adenocarcinoma ascertained by microarray analysis.通过微阵列分析确定的肺腺癌长链非编码RNA表达谱。
PLoS One. 2014 Aug 4;9(8):e104044. doi: 10.1371/journal.pone.0104044. eCollection 2014.
6
The incidences and mortalities of major cancers in China, 2010.2010年中国主要癌症的发病率和死亡率。
Chin J Cancer. 2014 Aug;33(8):402-5. doi: 10.5732/cjc.014.10084. Epub 2014 Jul 11.
7
Role of HOTAIR long noncoding RNA in metastatic progression of lung cancer.HOTAIR长链非编码RNA在肺癌转移进展中的作用
Eur Rev Med Pharmacol Sci. 2014 Jul;18(13):1930-6.
8
Emerging role of long non-coding RNA SOX2OT in SOX2 regulation in breast cancer.长链非编码RNA SOX2OT在乳腺癌SOX2调控中的新作用。
PLoS One. 2014 Jul 9;9(7):e102140. doi: 10.1371/journal.pone.0102140. eCollection 2014.
9
A long noncoding RNA Sox2ot regulates lung cancer cell proliferation and is a prognostic indicator of poor survival.一种长链非编码RNA Sox2ot调控肺癌细胞增殖，是生存预后不良的一个指标。
Int J Biochem Cell Biol. 2014 Aug;53:380-8. doi: 10.1016/j.biocel.2014.06.004. Epub 2014 Jun 10.
10
P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small cell lung cancer, partly through epigenetically regulating HOXB7 expression.P53调控的长链非编码RNA TUG1影响人非小细胞肺癌细胞的增殖，部分是通过表观遗传调控HOXB7的表达来实现的。
Cell Death Dis. 2014 May 22;5(5):e1243. doi: 10.1038/cddis.2014.201.

长链非编码RNA AFAP1-AS1的下调抑制肺腺癌肿瘤细胞的生长和侵袭。

Down-regulation of long non-coding RNA AFAP1-AS1 inhibits tumor cell growth and invasion in lung adenocarcinoma.

作者信息

Zhuang Yi, Jiang Hanyi, Li Hui, Dai Jinhong, Liu Yin, Li Yan, Miao Liyun, Cai Hourong, Xiao Yonglong, Xia Hongping, Wang Yongsheng, Shi Mingke

机构信息

Department of Respiratory Medicine, Drum Tower Hospital Affiliated to Medical School of Nanjing UniversityNanjing 210008, China.

Department of Pathology and Central Laboratory, Sir Run Run Shaw Hospital Affiliated to Nanjing Medical UniversityNanjing 211100, China.

出版信息

Am J Transl Res. 2017 Jun 15;9(6):2997-3005. eCollection 2017.

PMID:28670387
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5489899/
Abstract

An increasing number of deregulated long non-coding RNAs (lncRNA) have been implicated in cancer in humans, suggesting that lncRNAs may be involved in tumorigenesis or tumor progression. In previous investigations, lncRNA, AFAP1-AS1 has been found to be associated with several cancers, including nasopharyngeal carcinoma, lung cancer and esophageal adenocarcinoma. However, the function of AFAP1-AS1 in lung cancer has not been reported. In our present study, we found that AFAP1-AS1 was overexpressed in lung adenocarcinoma and associated with survival time. The low expression of AFAP1-AS1 was an independent predictor for disease-free survival in patients with lung adenocarcinoma. Additionally, we transfected AFAP1-AS1 siRNA into H1975 and HCC827, both lung adenocarcinoma cancer cells, and found that cell growth was suppressed, apoptosis induced and invasion inhibited. Taken together, AFAP1-AS1 down-regulation exerts growth suppression and apoptosis induction in lung adenocarcinoma cells, suggested it may participate in turmorigenesis and be a therapeutic target for treating lung adenocarcinoma in future.

摘要

越来越多失调的长链非编码RNA（lncRNA）与人类癌症相关，这表明lncRNAs可能参与肿瘤发生或肿瘤进展。在先前的研究中，已发现lncRNA AFAP1-AS1与多种癌症有关，包括鼻咽癌、肺癌和食管腺癌。然而，AFAP1-AS1在肺癌中的功能尚未见报道。在我们目前的研究中，我们发现AFAP1-AS1在肺腺癌中过表达并与生存时间相关。AFAP1-AS1的低表达是肺腺癌患者无病生存的独立预测因子。此外，我们将AFAP1-AS1 siRNA转染到两种肺腺癌细胞H1975和HCC827中，发现细胞生长受到抑制，凋亡被诱导，侵袭受到抑制。综上所述，AFAP1-AS1下调在肺腺癌细胞中发挥生长抑制和凋亡诱导作用，提示它可能参与肿瘤发生，并且在未来可能成为治疗肺腺癌的一个治疗靶点。