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跨越死亡之谷的桥梁:对佩尔·I·阿维德松的访谈

On the bridge over the translational valley of death: interview with Per I Arvidsson.

作者信息

Arvidsson Per I

机构信息

Science for Life Laboratory, Drug Discovery & Development Platform & Division of Translational Medicine & Chemical Biology, Department of Medical Biochemistry & Biophysics, Karolinska Institutet, Stockholm, Sweden.

Catalysis & Peptide Research Unit, University of KwaZulu Natal, Durban, South Africa.

出版信息

Future Sci OA. 2017 Apr 10;3(2):FSO183. doi: 10.4155/fsoa-2017-0019. eCollection 2017 Jun.

Abstract

Per received his PhD in organic chemistry from Gothenburg University (Sweden) in 1999, where he continued as a lecturer for a short time. Following 2 years at the ETH Zurich (Switzerland) as a postdoctoral fellow, he went on to establish an independent research group at the Department of Biochemistry and Organic Chemistry at Uppsala University (Sweden). In 2006, he joined AstraZeneca R&D Södertälje (Sweden). After 1-year in-house training for future leaders in drug discovery and development, he became team leader in Medicinal Chemistry in 2007. In 2008, he was appointed Candidate Drug Delivery team leader with responsibility for preclinical drug discoveries in several CNS and pain projects. In 2010, he became Project Director at the innovative medicine unit for CNS & Pain research in Södertälje with responsibility from lead optimization to end of Phase II for projects in the neurodegeneration area. After joining AstraZeneca, he continued to pursue academic research as Adjunct Professor in bioorganic chemistry at the Department of Biochemistry and Organic Chemistry, Uppsala University (2007-2010), and the Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry, Uppsala University (2010-2013). In 2010, he was appointed honorary professor in Pharmacy and Pharmacology at the University of KwaZulu Natal (South Africa). In 2013, he was recruited to the Karolinska Institute in Stockholm as Director of Drug Discovery & Development, to build up the National Swedish infrastructure for Drug Discovery & Development at the Science for Life Laboratory (SciLifeLab). Since 2013, he has been a part-time research professor at the College of Health Science at the University of KwaZulu Natal. He is named inventor on over 15 patent applications, and coauthor to over 100 publications, two of which have won 'most cited papers' awards.

摘要

佩尔于1999年在哥德堡大学(瑞典)获得有机化学博士学位,并在该校短暂担任讲师。在瑞士苏黎世联邦理工学院做了两年博士后之后,他在瑞典乌普萨拉大学的生物化学与有机化学系建立了一个独立的研究小组。2006年,他加入了阿斯利康研发公司(瑞典南泰利耶)。在接受了为期一年的药物研发未来领导者内部培训后,他于2007年成为药物化学团队负责人。2008年,他被任命为候选药物递送团队负责人,负责多个中枢神经系统和疼痛项目的临床前药物发现。2010年,他成为南泰利耶创新药物部门中枢神经系统与疼痛研究项目总监,负责神经退行性疾病领域项目从先导化合物优化到二期结束的工作。加入阿斯利康后,他继续从事学术研究,担任乌普萨拉大学生物化学与有机化学系(2007 - 2010年)以及乌普萨拉大学药物化学系有机药物化学专业(2010 - 2013年)的生物有机化学兼职教授。2010年,他被任命为南非夸祖鲁 - 纳塔尔大学药学与药理学荣誉教授。2013年,他被招募到斯德哥尔摩的卡罗琳斯卡学院担任药物发现与开发主任,在瑞典国家生命科学实验室(SciLifeLab)建立瑞典国家药物发现与开发基础设施。自2013年以来,他一直是夸祖鲁 - 纳塔尔大学健康科学学院的兼职研究教授。他是15项以上专利申请的发明人,也是100多篇出版物的共同作者,其中两篇获得了“高被引论文”奖。

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