用于通过正电子发射断层扫描评估脑衰老和阿尔茨海默病中代谢改变和生物金属通量的放射性药物。
Radiopharmaceuticals for Assessment of Altered Metabolism and Biometal Fluxes in Brain Aging and Alzheimer's Disease with Positron Emission Tomography.
作者信息
Xie Fang, Peng Fangyu
机构信息
Department of Radiology, and Advanced ImagingResearch Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
出版信息
J Alzheimers Dis. 2017;59(2):527-536. doi: 10.3233/JAD-170280.
Aging is a risk factor for Alzheimer's disease (AD). There are changes of brain metabolism and biometal fluxes due to brain aging, which may play a role in pathogenesis of AD. Positron emission tomography (PET) is a versatile tool for tracking alteration of metabolism and biometal fluxes due to brain aging and AD. Age-dependent changes in cerebral glucose metabolism can be tracked with PET using 2-deoxy-2-[18F]-fluoro-D-glucose (18F-FDG), a radiolabeled glucose analogue, as a radiotracer. Based on different patterns of altered cerebral glucose metabolism, 18F-FDG PET was clinically used for differential diagnosis of AD and Frontotemporal dementia (FTD). There are continued efforts to develop additional radiopharmaceuticals or radiotracers for assessment of age-dependent changes of various metabolic pathways and biometal fluxes due to brain aging and AD with PET. Elucidation of age-dependent changes of brain metabolism and altered biometal fluxes is not only significant for a better mechanistic understanding of brain aging and the pathophysiology of AD, but also significant for identification of new targets for the prevention, early diagnosis, and treatment of AD.
衰老为阿尔茨海默病（AD）的一个风险因素。脑衰老会导致脑代谢和生物金属通量发生变化，这可能在AD的发病机制中发挥作用。正电子发射断层扫描（PET）是一种通用工具，可用于追踪脑衰老和AD导致的代谢及生物金属通量改变。使用2-脱氧-2-[18F]-氟-D-葡萄糖（18F-FDG），一种放射性标记的葡萄糖类似物作为放射性示踪剂，PET能够追踪脑葡萄糖代谢随年龄的变化。基于脑葡萄糖代谢改变的不同模式，18F-FDG PET在临床上用于AD与额颞叶痴呆（FTD）的鉴别诊断。人们持续致力于开发其他放射性药物或放射性示踪剂，以利用PET评估脑衰老和AD导致的各种代谢途径及生物金属通量的年龄依赖性变化。阐明脑代谢的年龄依赖性变化以及生物金属通量改变，不仅对于更好地从机制上理解脑衰老和AD的病理生理学具有重要意义，而且对于确定AD预防、早期诊断和治疗的新靶点也具有重要意义。
Zotero 插件