Departament d'Enginyeria Química (EEBE) and Barcelona Research Center for Multiscale Science and Engineering, Universitat Politècnica de Catalunya, C/Eduard Maristany, 10-14, Ed. I2, 08019, Barcelona, Spain.
Adv Healthc Mater. 2017 Sep;6(18). doi: 10.1002/adhm.201700453. Epub 2017 Jul 3.
Poly(3,4-ethylenedioxythiophene) (PEDOT) nanoparticles are loaded with curcumin and piperine by in situ emulsion polymerization using dodecyl benzene sulfonic acid both as a stabilizer and a doping agent. The loaded drugs affect the morphology, size, and colloidal stability of the nanoparticles. Furthermore, kinetics studies of nonstimulated drug release have evidenced that polymer···drug interactions are stronger for curcumin than for piperine. This observation suggests that drug delivery systems based on combination of the former drug with PEDOT are much appropriated to show an externally tailored release profile. This is demonstrated by comparing the release profiles obtained in presence and absence of electrical stimulus. Results indicate that controlled and time-programmed release of curcumin is achieved in a physiological medium by applying a negative voltage of -1.25 V to loaded PEDOT nanoparticles.
聚（3,4-亚乙基二氧噻吩）（PEDOT）纳米粒子通过使用十二烷基苯磺酸作为稳定剂和掺杂剂的原位乳液聚合来负载姜黄素和胡椒碱。负载的药物会影响纳米粒子的形态、大小和胶体稳定性。此外，非刺激药物释放的动力学研究表明，聚合物与药物的相互作用对于姜黄素而言比胡椒碱更强。这一观察结果表明，基于将前一种药物与 PEDOT 结合的药物递送系统非常适合显示外部定制的释放曲线。通过比较在存在和不存在电刺激时获得的释放曲线来证明这一点。结果表明，通过向负载的 PEDOT 纳米粒子施加-1.25 V 的负电压，可以在生理介质中实现姜黄素的控制和时间编程释放。
