Johansson M E
J Pharm Pharmacol. 1985 Oct;37(10):681-5. doi: 10.1111/j.2042-7158.1985.tb04942.x.
Magnesium stearate has been granulated in four ways to produce lubricant granulations with different properties. The lubricating properties, as well as the tablet properties with the granulated lubricant, were evaluated on tablets prepared from a mixture of dicalcium phosphate, corn starch and microcrystalline cellulose. The lubricating effect of the magnesium stearate granulations showed a similar pattern regardless of the granulation technique used except for a granulation with providone. Increasing the particle size of the magnesium stearate granulation increased the amount of lubricant required to obtain lubrication similar to powdered magnesium stearate. Variations in the specific surface area of the starting materials could be masked by using them in granular form.
硬脂酸镁已通过四种方式制粒，以生产具有不同性质的润滑剂颗粒。在由磷酸二钙、玉米淀粉和微晶纤维素的混合物制备的片剂上，评估了润滑性能以及使用粒状润滑剂时的片剂性能。除了用聚维酮制粒外，无论使用何种制粒技术，硬脂酸镁颗粒的润滑效果都呈现出相似的模式。增大硬脂酸镁颗粒的粒径会增加获得与硬脂酸镁粉末相似润滑效果所需的润滑剂用量。通过以颗粒形式使用起始原料，可以掩盖其比表面积的变化。
