MOE Key Laboratory of Laser Life Science & SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology, College of Biophotonics, South China Normal University , Guangzhou 510631, Guangdong, China.
ACS Appl Mater Interfaces. 2017 Aug 2;9(30):25098-25106. doi: 10.1021/acsami.7b05824. Epub 2017 Jul 20.
A multifunctional nanoplatform based on black phosphorus quantum dots (BPQDs) was developed for cancer bioimaging and combined photothermal therapy (PTT) and photodynamic therapy (PDT). BPQDs were functionalized with PEG chains to achieve improved biocompatibility and physiological stability. The as-prepared nanoparticles exhibite prominent near-infrared (NIR) photothermal and red-light-triggered photodynamic properties. The combined therapeutic application of PEGylated BPQDs were then performed in vitro and in vivo. The results demonstrate that the combined phototherapy significantly promote the therapeutic efficacy of cancer treatment in comparison with PTT or PDT alone. BPQDs could also serve as the loading platform for fluorescent molecules, allowing reliable imaging of cancer cells. In addition, the low cytotoxicity and negligible side effects to main organs were observed in toxicity experiments. The theranostic characteristics of PEGylated BPQDs provide an uplifting potential for the future clinical applications.
一种基于黑磷量子点（BPQDs）的多功能纳米平台被开发用于癌症生物成像，并结合了光热疗法（PTT）和光动力疗法（PDT）。BPQDs 通过 PEG 链进行功能化，以实现更好的生物相容性和生理稳定性。所制备的纳米粒子表现出突出的近红外（NIR）光热和红光触发光动力特性。随后在体外和体内进行了 PEGylated BPQDs 的联合治疗应用。结果表明，与单独的 PTT 或 PDT 相比，联合光疗显著提高了癌症治疗的疗效。BPQDs 还可以作为荧光分子的负载平台，实现对癌细胞的可靠成像。此外，在毒性实验中观察到低细胞毒性和对主要器官的微小副作用。PEGylated BPQDs 的治疗特性为未来的临床应用提供了很大的潜力。
