Zhang Wanheng, Yu Liting, Jiang Yin, Guo Changying
School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, P.R. China.
Biomater Sci. 2021 Aug 7;9(15):5302-5318. doi: 10.1039/d1bm00106j. Epub 2021 Jun 29.
To achieve synergistic photodynamic-photothermic therapy, we fabricate the novel phycocyanin (PC)-functionalized black phosphorus quantum dots (BPQDs) referred as PC@BPQDs through a one-step stirring method. PC@BPQDs are characterized by the feature of possessing both near-infrared (NIR) induced photothermal and photodynamic activity. The PC layer not only effectively alleviates plasma protein adsorption onto BPQDs, but also functionally boosts the photothermal therapy efficiency by enhanced ROS release, resulting in increased apoptosis in vitro. Moreover, PC@BPQDs eradicate tumors with high efficacy and low toxicity in vivo. Thus, PC@BPQDs have a promising potential in future therapeutic implications.
为实现协同光动力-光热疗法，我们通过一步搅拌法制备了新型藻蓝蛋白（PC）功能化的黑磷量子点（BPQDs），即PC@BPQDs。PC@BPQDs具有近红外（NIR）诱导的光热和光动力活性。PC层不仅有效减轻了血浆蛋白在BPQDs上的吸附，还通过增强活性氧（ROS）释放从功能上提高了光热治疗效率，导致体外细胞凋亡增加。此外，PC@BPQDs在体内能高效低毒地根除肿瘤。因此，PC@BPQDs在未来治疗应用中具有广阔的潜力。
