Buss D C, Routledge P A
J Pharm Pharmacol. 1985 Sep;37(9):669-70. doi: 10.1111/j.2042-7158.1985.tb05111.x.
It has been reported that amiodarone may interact with digoxin in man. We investigated the effects of amiodarone pretreatment (35 mg kg-1 day-1) on the pharmacokinetics of a single dose of digoxin (50 micrograms kg-1) in 6 rabbits. Total body clearance of digoxin was 138.84 +/- 44.67 and 147.99 +/- 29.17 ml min-1, serum half life 187.9 +/- 60.9 and 181.34 +/- 25.57 min and volume of distribution 35.4 +/- 8.54 and 37.8 +/- 3.9 litres before and after amiodarone treatment, respectively. None of these changes were statistically significant. We conclude that the presence of an amiodarone-induced change in digoxin pharmacokinetics in the rabbit was not evident and that other animal models will be necessary for studying this interaction.
据报道，胺碘酮可能与人的地高辛发生相互作用。我们研究了胺碘酮预处理（35毫克/千克/天）对6只兔子单剂量地高辛（50微克/千克）药代动力学的影响。胺碘酮治疗前后，地高辛的总体清除率分别为138.84±44.67和147.99±29.17毫升/分钟，血清半衰期分别为187.9±60.9和181.34±25.57分钟，分布容积分别为35.4±8.54和37.8±3.9升。这些变化均无统计学意义。我们得出结论，在兔子中，胺碘酮诱导的地高辛药代动力学变化不明显，研究这种相互作用需要其他动物模型。
