Xia Ning, Förstermann Ulrich, Li Huige
Department of Pharmacology, Johannes Gutenberg University Medical Center, Mainz, Germany.
Center for Translational Vascular Biology (CTVB), Johannes Gutenberg University Medical Center, Mainz, Germany.
Ann N Y Acad Sci. 2017 Sep;1403(1):132-141. doi: 10.1111/nyas.13397. Epub 2017 Jul 3.
Under physiological conditions, nitric oxide (NO) is produced in the vasculature mainly by the endothelial NO synthase (eNOS). Experiments using gene-disrupted mice have demonstrated that eNOS has antihypertensive, antithrombotic, and antiatherosclerotic effects. Recent studies show that eNOS is expressed not only in the endothelium but also in the perivascular adipose tissue (PVAT). Resveratrol prevents eNOS uncoupling and upregulates eNOS expression and activity. These effects of resveratrol are well established for the eNOS enzyme in the endothelium. Interestingly, resveratrol also improves PVAT function. However, a causal role for eNOS in the effects of resveratrol on PVAT function has not yet been verified and needs to be studied in the future.
在生理条件下，一氧化氮（NO）主要由血管内皮一氧化氮合酶（eNOS）在脉管系统中产生。使用基因敲除小鼠进行的实验表明，eNOS具有抗高血压、抗血栓形成和抗动脉粥样硬化作用。最近的研究表明，eNOS不仅在内皮中表达，也在血管周围脂肪组织（PVAT）中表达。白藜芦醇可防止eNOS解偶联，并上调eNOS的表达和活性。白藜芦醇的这些作用在内皮中的eNOS酶方面已得到充分证实。有趣的是，白藜芦醇还可改善PVAT功能。然而，eNOS在白藜芦醇对PVAT功能影响中的因果作用尚未得到证实，有待未来研究。
