Ling Samantha S M, Chen Yei-Tsung, Wang Juan, Richards Arthur M, Liew Oi Wah
Cardiovascular Research Institute, National University Health System, Singapore 119228, Singapore.
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore.
Int J Mol Sci. 2017 Jun 26;18(7):1362. doi: 10.3390/ijms18071362.
The ankyrin repeat domain 1 (ANKRD1) protein is a cardiac-specific stress-response protein that is part of the muscle ankyrin repeat protein family. ANKRD1 is functionally pleiotropic, playing pivotal roles in transcriptional regulation, sarcomere assembly and mechano-sensing in the heart. Importantly, cardiac ANKRD1 has been shown to be highly induced in various cardiomyopathies and in heart failure, although it is still unclear what impact this may have on the pathophysiology of heart failure. This review aims at highlighting the known properties, functions and regulation of ANKRD1, with focus on the underlying mechanisms that may be involved. The current views on the actions of ANKRD1 in cardiovascular disease and its utility as a candidate cardiac biomarker with diagnostic and/or prognostic potential are also discussed. More studies of ANKRD1 are warranted to obtain deeper functional insights into this molecule to allow assessment of its potential clinical applications as a diagnostic or prognostic marker and/or as a possible therapeutic target.
锚蛋白重复结构域1（ANKRD1）蛋白是一种心脏特异性应激反应蛋白，属于肌肉锚蛋白重复蛋白家族。ANKRD1功能多样，在心脏的转录调控、肌节组装和机械传感中发挥关键作用。重要的是，尽管尚不清楚这对心力衰竭的病理生理学有何影响，但已证明心脏ANKRD1在各种心肌病和心力衰竭中高度诱导表达。本综述旨在突出ANKRD1的已知特性、功能和调控，重点关注可能涉及的潜在机制。还讨论了目前关于ANKRD1在心血管疾病中的作用及其作为具有诊断和/或预后潜力的候选心脏生物标志物的效用的观点。有必要对ANKRD1进行更多研究，以更深入地了解该分子的功能，从而评估其作为诊断或预后标志物和/或可能的治疗靶点的潜在临床应用。
