锚蛋白重复域蛋白 1 的研究进展：最新综述。

Maternal and Child Research Institute, Shunde Women and Children Hospital, Guangdong Medical University, Foshan, 528300, China.

Department of Neurology, Longjiang Hospital, Foshan, 528300, China.

Cell Mol Biol Lett. 2024 Oct 17;29(1):131. doi: 10.1186/s11658-024-00647-w.

Ankyrin repeat domain 1 (Ankrd1) is an acute response protein that belongs to the muscle ankyrin repeat protein (MARP) family. Accumulating evidence has revealed that Ankrd1 plays a crucial role in a wide range of biological processes and diseases. This review consolidates current knowledge on Ankrd1's functions in myocardium and skeletal muscle development, neurogenesis, cancer, bone formation, angiogenesis, wound healing, fibrosis, apoptosis, inflammation, and infection. The comprehensive profile of Ankrd1 in cardiovascular diseases, myopathy, and its potential as a candidate prognostic and diagnostic biomarker are also discussed. In the future, more studies of Ankrd1 are warranted to clarify its role in diseases and assess its potential as a therapeutic target.

锚蛋白重复结构域 1（Ankrd1）是一种急性反应蛋白，属于肌肉锚蛋白重复蛋白（MARP）家族。越来越多的证据表明，Ankrd1 在广泛的生物学过程和疾病中发挥着关键作用。本综述总结了 Ankrd1 在心肌和骨骼肌发育、神经发生、癌症、骨形成、血管生成、伤口愈合、纤维化、细胞凋亡、炎症和感染中的功能的最新知识。还讨论了 Ankrd1 在心血管疾病、肌病中的综合概况及其作为候选预后和诊断生物标志物的潜力。未来需要更多的 Ankrd1 研究来阐明其在疾病中的作用，并评估其作为治疗靶点的潜力。