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使用猪模型评估不可逆电穿孔对胃壁的安全性。

Evaluation of the safety of irreversible electroporation on the stomach wall using a pig model.

作者信息

Li Jiannan, Zeng Jianying, Chen Jibing, Shi Jian, Luo Xiaomei, Fang Gang, Chai Wei, Zhang Wenlong, Liu Tongjun, Niu Lizhi

机构信息

Department of General Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.

Department of Central Laboratory, Fuda Cancer Hospital, Jinan University School of Medicine, Guangzhou, Guangdong 510665, P.R. China.

出版信息

Exp Ther Med. 2017 Jul;14(1):696-702. doi: 10.3892/etm.2017.4559. Epub 2017 Jun 7.

DOI:10.3892/etm.2017.4559
PMID:28672987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5488745/
Abstract

The aim of the present study was to evaluate the effects of irreversible electroporation (IRE) on the stomach wall following the direct application of IRE onto the organ surface. IRE ablation was performed in 8 Tibetan mini-pigs, which were randomly assigned into two groups based on their ablated areas: Group A, gastric cardia, fundus of stomach, gastric body and group B, lesser gastric curvature, greater gastric curvature, stomach pylorus. Two IRE needles were placed in the space between the stomach wall and the liver (not inserted into the stomach tissue), and three lesions were created in each pig. Serum aminotransferase and white blood cell (WBC) levels were measured. Gastroscopy and endoscopic ultrasonography were performed. From each group, 2 pigs were sacrificed on day 7 post-IRE; the remaining pigs were sacrificed on day 28 post-IRE. There were no signs of perforation on the stomach wall. Serum aminotransferase and WBC levels increased in both groups on day 1 post-IRE and decreased gradually thereafter. The gastroscopy procedure revealed oval ulcers on day 7 post-IRE and smaller ulcers on day 28 post-IRE. Transmural necrosis, inflammation and fibrosis were observed at 7 days post-IRE. Healing ulcers were observed at 28 days post-IRE. In conclusion, IRE ablation caused damage to the stomach wall; however, IRE did not induce any perforation.

摘要

本研究的目的是评估在将不可逆电穿孔（IRE）直接应用于胃表面后，其对胃壁的影响。对8只西藏小型猪进行IRE消融，根据消融区域将其随机分为两组：A组，贲门、胃底、胃体；B组，胃小弯、胃大弯、胃幽门。将两根IRE针置于胃壁与肝脏之间的间隙（未插入胃组织），每只猪制造三个损伤灶。测量血清转氨酶和白细胞（WBC）水平。进行胃镜检查和内镜超声检查。每组在IRE后第7天处死2只猪；其余猪在IRE后第28天处死。胃壁未见穿孔迹象。两组在IRE后第1天血清转氨酶和WBC水平均升高，此后逐渐下降。胃镜检查显示IRE后第7天出现椭圆形溃疡，IRE后第28天溃疡变小。IRE后7天观察到透壁坏死、炎症和纤维化。IRE后28天观察到溃疡愈合。总之，IRE消融对胃壁造成了损伤；然而，IRE并未引起任何穿孔。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a77/5488745/70f923366b7d/etm-14-01-0696-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a77/5488745/487e63ceb25a/etm-14-01-0696-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a77/5488745/37a5d7b95738/etm-14-01-0696-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a77/5488745/c058b304aad2/etm-14-01-0696-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a77/5488745/907bc92c8f1f/etm-14-01-0696-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a77/5488745/d347f03d8c09/etm-14-01-0696-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a77/5488745/8ba8313026bd/etm-14-01-0696-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a77/5488745/70f923366b7d/etm-14-01-0696-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a77/5488745/487e63ceb25a/etm-14-01-0696-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a77/5488745/37a5d7b95738/etm-14-01-0696-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a77/5488745/c058b304aad2/etm-14-01-0696-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a77/5488745/907bc92c8f1f/etm-14-01-0696-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a77/5488745/d347f03d8c09/etm-14-01-0696-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a77/5488745/8ba8313026bd/etm-14-01-0696-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a77/5488745/70f923366b7d/etm-14-01-0696-g06.jpg

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