Collaborative Antwerp Psychiatric Research Institute, Building A, Campus Drie Eiken, Universiteitsplein 1, B-2610 Antwerp, Belgium; Psychiatric University Hospital Antwerp, Campus Duffel, Stationstraat 22c, Duffel, Belgium.
Psychiatric University Hospital Antwerp, Campus Duffel, Stationstraat 22c, Duffel, Belgium.
Schizophr Res. 2018 Oct;200:92-96. doi: 10.1016/j.schres.2017.06.047. Epub 2017 Jun 30.
The aim of this study is to assess to what extent psychomotor assessment can aid the clinician in differentiating between schizophrenia and other psychotic disorders.
Enrolled subjects were recent in remission patients (n=304), who all met DSM-IV (APA, 2013) criteria for either schizophrenia (Sz; n=117), schizoaffective disorder (SaD; n=36), psychotic disorder not otherwise specified (P-NOS) (n=86), substance/medication-induced psychotic disorder (SIPD; n=33) or major depressive disorder with psychotic features (MDD-p; n=32). The patients were submitted to a psychomotor test battery.
Patients with schizophrenia generally perform worse on most tests. Using cluster analysis a combination of three tests, namely the sensory integration subscale of the Neurological Evaluation Scale (NES), a Figure Copying Task (FCT) and the finger tapping test (FTT), came out to be useful to clinically differentiate between schizophrenia and substance-induced psychotic disorder (SIPD) or psychosis not otherwise specified (P-NOS). When comparing schizophrenia only to a group of patients with SIPD, the differentiation potential becomes even greater with a 76.1% chance to correctly diagnose patients with schizophrenia and 75% chance for patients with SIPD.
A combination of NES, FCT and FTT shows promising results as a clinical tool in daily practice to differentiate schizophrenia from other psychotic disorders. Future prospective studies to confirm these results are necessary.
本研究旨在评估精神运动评估在多大程度上有助于临床医生区分精神分裂症和其他精神病性障碍。
入组的受试者为近期缓解的患者（n=304），均符合 DSM-IV（APA，2013）标准，诊断为精神分裂症（Sz；n=117）、分裂情感障碍（SaD；n=36）、未特定的精神病性障碍（P-NOS）（n=86）、物质/药物引起的精神病性障碍（SIPD；n=33）或伴有精神病特征的重性抑郁障碍（MDD-p；n=32）。患者接受了精神运动测试组合。
精神分裂症患者在大多数测试中表现普遍较差。使用聚类分析，将神经评估量表（NES）的感觉整合子量表、图形复制任务（FCT）和手指敲击测试（FTT）三种测试相结合，可用于临床区分精神分裂症和物质引起的精神病性障碍（SIPD）或未特定的精神病性障碍（P-NOS）。当将精神分裂症与仅一组 SIPD 患者进行比较时，正确诊断精神分裂症患者的可能性增加到 76.1%，SIPD 患者的可能性增加到 75%，区分潜力更大。
NES、FCT 和 FTT 的组合显示出作为一种临床工具在日常实践中区分精神分裂症和其他精神病性障碍的有希望的结果。未来有必要进行前瞻性研究来证实这些结果。
