Chan Jia Mun, Dillard Joseph P
Department of Medical Microbiology & Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Department of Medical Microbiology & Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA
J Bacteriol. 2017 Sep 19;199(20). doi: 10.1128/JB.00354-17. Print 2017 Oct 15.
Maintenance of the structural macromolecule peptidoglycan (PG), which involves regulated cycles of PG synthesis and PG degradation, is pivotal for cellular integrity and survival. PG fragments generated from the degradation process are usually efficiently recycled by Gram-negative bacteria. However, and a limited number of Gram-negative bacteria release PG fragments in amounts sufficient to induce host tissue inflammation and damage during an infection. Due to limited redundancy in PG-modifying machineries and genetic tractability, serves as a great model organism for the study of biological processes related to PG. This review summarizes the generation, modification, and release of inflammatory PG molecules by and related species and discusses these findings in the context of understanding bacterial physiology and pathogenesis.
结构大分子肽聚糖（PG）的维持涉及PG合成和PG降解的调节循环，对细胞完整性和存活至关重要。降解过程产生的PG片段通常被革兰氏阴性菌有效回收利用。然而，少数革兰氏阴性菌在感染期间释放出足以诱导宿主组织炎症和损伤的PG片段。由于PG修饰机制的冗余性有限且具有遗传易处理性，[具体细菌名称未给出]成为研究与PG相关生物学过程的理想模式生物。本综述总结了[具体细菌名称未给出]及相关物种产生、修饰和释放炎性PG分子的情况，并在理解细菌生理学和发病机制的背景下讨论了这些发现。
