Kumfor Fiona, Halliday Glenda M, Piguet Olivier
School of Psychology, Central Medical School and Brain & Mind Centre, University of Sydney, Mallett St, Sydney, 2006, NSW, Australia.
Adv Neurobiol. 2017;15:31-53. doi: 10.1007/978-3-319-57193-5_2.
Alzheimer's disease is the most common form of dementia accounting for 50-60% of all dementia cases. This chapter briefly reviews the history of Alzheimer's disease and provides an overview of the clinical syndromes associated with Alzheimer pathology and their associated neuroimaging findings. This chapter also reviews the neuropathology and genetics of Alzheimer's disease and concludes by discussing current work undertaken to identify suitable in vivo biomarkers for the disease.
阿尔茨海默病是最常见的痴呆形式,占所有痴呆病例的50%-60%。本章简要回顾了阿尔茨海默病的历史,并概述了与阿尔茨海默病理相关的临床综合征及其相关的神经影像学表现。本章还回顾了阿尔茨海默病的神经病理学和遗传学,并通过讨论目前为确定该疾病合适的体内生物标志物所开展的工作来结束本章。