Bernstein J, Fisher R S
Neurosci Lett. 1985 Oct 24;61(1-2):19-24. doi: 10.1016/0304-3940(85)90394-5.
Exposure of rat hippocampal slices to perfusate containing 1-2 mM glutamate (GLU) induces reversible and relatively selective blockade of excitatory transmission. Intracellular recordings from 20 region CA1 hippocampal cells demonstrated only transient and mild effects on resting membrane properties and action potentials. In contrast, in 2 mM GLU excitatory postsynaptic potentials declined to 28% of control (P less than 0.001); inhibitory postsynaptic potentials remained robust at 88% of control. This suggests that excess exposure to GLU may result in a selective 'down-regulation' of excitatory synaptic transmission, while preserving inhibitory pathways. These observations may have practical implications for development of new anticonvulsant drugs.
将大鼠海马切片暴露于含有1-2 mM谷氨酸（GLU）的灌注液中会诱导兴奋性传递的可逆且相对选择性阻断。对20个海马CA1区细胞进行的细胞内记录表明，对静息膜特性和动作电位仅有短暂且轻微的影响。相比之下，在2 mM GLU中，兴奋性突触后电位降至对照值的28%（P小于0.001）；抑制性突触后电位保持强劲，为对照值的88%。这表明过量暴露于GLU可能导致兴奋性突触传递的选择性“下调”，同时保留抑制性通路。这些观察结果可能对新型抗惊厥药物的开发具有实际意义。
