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心脏结节病:诊断与治疗的挑战

Cardiac sarcoidosis: a diagnostic and therapeutic challenge.

作者信息

Timmers Marijke, Claeys Marc J, Vanhauwaert Bert, Rivero-Ayerza Maximo, De Hondt Geert

机构信息

a Department of Cardiology , University Hospital Antwerp , Antwerp , Belgium.

b Department of Cardiology , Mariaziekenhuis Noord-Limburg , Overpelt , Belgium.

出版信息

Acta Cardiol. 2018 Feb;73(1):1-6. doi: 10.1080/00015385.2017.1325633. Epub 2017 Jul 4.

DOI:10.1080/00015385.2017.1325633
PMID:28675086
Abstract

OBJECTIVE

Cardiac involvement in sarcoidosis can present in various ways, with atrioventricular (AV) block and ventricular arrhythmias being the most common signs. Because of initial non-specific findings, diagnosis can be a challenge. Very few data can support treatment decisions as cardiac manifestations of this systemic disorder are rare.

METHODS AND RESULTS

We reviewed current guidelines, cohort studies, and expert opinions concerning diagnosis and treatment of cardiac sarcoidosis.

CONCLUSIONS

Longitudinal follow-up studies are necessary to improve the diagnostic process and risk stratification of cardiac sarcoidosis. The optimal dose of steroids, indications for internal cardioverter-defibrillator (ICD), and technique and optimal timing of ablation are still under debate.

摘要

目的

结节病累及心脏可表现为多种形式,其中房室传导阻滞和室性心律失常最为常见。由于最初表现不具特异性,诊断可能具有挑战性。由于这种全身性疾病的心脏表现罕见,几乎没有数据能够支持治疗决策。

方法与结果

我们回顾了有关心脏结节病诊断和治疗的现行指南、队列研究及专家意见。

结论

有必要进行纵向随访研究以改善心脏结节病的诊断流程和风险分层。类固醇的最佳剂量、植入式心脏复律除颤器(ICD)的适应证以及消融技术和最佳时机仍存在争议。

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引用本文的文献

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Cardiac sarcoidosis: a comprehensive review of risk factors, pathogenesis, diagnosis, clinical manifestations, and treatment strategies.心脏结节病:危险因素、发病机制、诊断、临床表现及治疗策略的全面综述
Front Cardiovasc Med. 2023 May 19;10:1156474. doi: 10.3389/fcvm.2023.1156474. eCollection 2023.
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Ten Questions Cardiologists Should Be Able to Answer About Cardiac Sarcoidosis: Case-Based Approach and Contemporary Review.心脏病专家应能回答的关于心脏结节病的十个问题:基于病例的方法与当代综述
CJC Open. 2020 Dec 26;3(4):532-548. doi: 10.1016/j.cjco.2020.11.022. eCollection 2021 Apr.
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Exercise-induced torsades de pointes as an unusual presentation of cardiac sarcoidosis: A case report and review of literature.
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World J Cardiol. 2020 Jun 26;12(6):291-302. doi: 10.4330/wjc.v12.i6.291.