Sarathy K, Alexopoulos C
K Sarathy, Port Macquarie Base Hospital, Port Macquarie, NSW, Australia. Email:
J R Coll Physicians Edinb. 2017 Jun;47(2):146-147. doi: 10.4997/JRCPE.2017.209.
Clozapine-induced myopericarditis is a well-described adverse drug reaction. Clozapine is also the most efficacious agent in refractory schizophrenia. We report a case of a patient who was successfully re-trialled on clozapine two years after developing myopericarditis, after which multiple lines of alternative treatment failed. We propose a protocol for safely attempting a re-trial of clozapine in such cases.
氯氮平诱发的心肌心包炎是一种已被充分描述的药物不良反应。氯氮平也是治疗难治性精神分裂症最有效的药物。我们报告了一例患者，该患者在发生心肌心包炎两年后成功重新试用氯氮平，此前多种替代治疗均失败。我们提出了一个在此类病例中安全尝试重新试用氯氮平的方案。
