Oliva Alessandra, Cipolla Alessia, Vullo Vincenzo, Venditti Mario, Mastroianni Claudio Maria, Falcone Marco
Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, Italy.
New Microbiol. 2017 Jul;40(3):205-207. Epub 2017 Jul 4.
We present the case of a patient with ventilator-associated pneumonia (VAP) caused by a pan-resistant Acinetobacter baumannii successfully treated with the combination colistin plus vancomycin plus rifampin, whose in vitro activity was investigated by checkerboard method and killing testing. Furthermore, the serum bactericidal activity (SBA) was assessed. Our case shows that an innovative regimen consisting of colistin plus antimicrobials active only against Gram-positive microorganisms might represent a valid therapeutic option for severe infections caused by colistin-resistant A. baumannii.
我们报告了一例由泛耐药鲍曼不动杆菌引起的呼吸机相关性肺炎（VAP）患者，该患者采用黏菌素联合万古霉素加利福平成功治疗，通过棋盘法和杀菌试验研究了其体外活性。此外，还评估了血清杀菌活性（SBA）。我们的病例表明，由黏菌素加仅对革兰氏阳性微生物有活性的抗菌药物组成的创新方案可能是治疗由耐黏菌素鲍曼不动杆菌引起的严重感染的有效治疗选择。
