DNA还是蛋白质？毛细管区带电泳-质谱法可快速阐明金属药物的结合选择性。
DNA or protein? Capillary zone electrophoresis-mass spectrometry rapidly elucidates metallodrug binding selectivity.
作者信息
Artner Christian, Holtkamp Hannah U, Kandioller Wolfgang, Hartinger Christian G, Meier-Menches Samuel M, Keppler Bernhard K
机构信息
Institute of Inorganic Chemistry, University of Vienna, Faculty of Chemistry, Waehringer Str. 42, 1090 Vienna, Austria.
出版信息
Chem Commun (Camb). 2017 Jul 13;53(57):8002-8005. doi: 10.1039/c7cc04582d.
PMID:28675406
Abstract
A novel capillary zone electrophoresis-mass spectrometry (CZE-MS) approach allows the simultaneous characterization and quantification of the binding of metal-based anticancer agents to biomolecules. Moreover, for the first time, oligonucleotide metallation was resolved at single-nucleotide resolution by MS.
摘要
一种新型的毛细管区带电泳-质谱联用（CZE-MS）方法能够同时对金属基抗癌药物与生物分子的结合进行表征和定量。此外，质谱首次实现了以单核苷酸分辨率解析寡核苷酸金属化。
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