Bissette G, Nemeroff C B
Prog Clin Biol Res. 1985;192:349-53.
Neuroleptic drugs are used in psychiatry for their antipsychotic actions. The current pharmacological hypothesis for their mechanism of action is largely based on the correlation between their potency to block dopamine (DA) receptors with their antipsychotic actions. Recently, the effect of chronic neuroleptic treatment on the concentrations of three neuropeptides, methionine-enkephalin (Met-ENK), cholecystokinin octapeptide (CCK-8) and neurotensin (NT), has been studied. These data are reviewed and evaluated in light of the possibility that neuroleptic drug action may be mediated, in part, through alterations in neuropeptide systems.
抗精神病药物因其抗精神病作用而用于精神病学领域。目前关于其作用机制的药理学假说主要基于它们阻断多巴胺（DA）受体的效力与其抗精神病作用之间的相关性。最近，研究了长期使用抗精神病药物治疗对三种神经肽，即甲硫氨酸脑啡肽（Met-ENK）、八肽胆囊收缩素（CCK-8）和神经降压素（NT）浓度的影响。鉴于抗精神病药物的作用可能部分通过神经肽系统的改变来介导，对这些数据进行了综述和评估。
