肺炎球菌结合疫苗时代镰状细胞病患儿的侵袭性肺炎球菌疾病
Invasive pneumococcal disease in children with sickle cell disease in the pneumococcal conjugate vaccine era.
作者信息
Martin Olufunke O, Moquist Kristin L, Hennessy Jane M, Nelson Stephen C
机构信息
Medical Student, Michigan State University College of Human Medicine, Flint, Michigan.
Department of Pediatric Hematology-Oncology, Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota.
出版信息
Pediatr Blood Cancer. 2018 Jan;65(1). doi: 10.1002/pbc.26713. Epub 2017 Jul 4.
Invasive pneumococcal disease (IPD) in children with sickle cell disease (SCD) can be devastating. We sought to assess the impact of IPD in children with SCD since licensure of the pneumococcal conjugate vaccines (PCVs). We found 11 cases of IPD giving an incidence of 417 per 100,000 person-years, much higher than that reported in children without SCD. Although all isolates were sensitive to penicillin, 89% of isolates were nonvaccine serotypes. Further study is needed to characterize the incidence of and risk factors for the development of IPD in SCD in the PCV era to help drive better prevention strategies.
镰状细胞病（SCD）患儿发生侵袭性肺炎球菌疾病（IPD）可能是灾难性的。自肺炎球菌结合疫苗（PCV）获批以来，我们试图评估IPD对SCD患儿的影响。我们发现了11例IPD病例，发病率为每10万人年417例，远高于非SCD患儿的报告发病率。尽管所有分离株对青霉素敏感，但89%的分离株属于非疫苗血清型。需要进一步研究以明确PCV时代SCD患儿IPD的发病率及发病危险因素，从而推动制定更好的预防策略。
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