磷酸化核糖体蛋白S6与口腔鳞状细胞癌中p21表达的相关性及与肿瘤大小的负相关关系。
Phosphorylated ribosomal protein S6 correlation with p21 expression and inverse association with tumor size in oral squamous cell carcinoma.
作者信息
de Vicente Juan C, Peña Ignacio, Rodrigo Juan P, Rodríguez-Santamarta Tania, Lequerica-Fernández Paloma, Suárez-Fernández Laura, Allonca Eva, García-Pedrero Juana M
机构信息
Department of Oral and Maxillofacial Surgery, Hospital Universitario Central de Asturias (HUCA), Oviedo, Asturias, Spain.
Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Hospital Universitario Central de Asturias, Oviedo, Asturias, CIBERONC ISCIII Spain.
出版信息
Head Neck. 2017 Sep;39(9):1876-1887. doi: 10.1002/hed.24854. Epub 2017 Jul 4.
BACKGROUND
The purpose of this study was to investigate the clinical relevance of phosphorylated ribosomal protein S6 (p-S6), a surrogate marker of mammalian target of rapamycin (mTOR) activation, and p21 in a series of 125 patients with oral squamous cell carcinomas (OSCCs).
METHODS
Immunohistochemical analysis was performed to ascertain the phosphorylation status of p-S6 at Ser235/236 and Ser240/244, p21, and p53 protein expression.
RESULTS
Expression of phosphorylated S6 protein on either serine 235/236 or serine 240/244 was detected in 83% and 88% tumors, respectively, and both of them were inversely and significantly correlated with the tumor size and local infiltration. Positive p21 expression was found in 91.5% of the cases, and was inversely correlated with tumor size. In OSCC, p21 expression correlates with p-S6 levels, a surrogate marker of mTOR activation, independently of p53 status.
CONCLUSION
Expression of both p21 and p-S6 was found to inversely associate with tumor size but not survival outcomes in patients with OSCC.
背景
本研究旨在调查磷酸化核糖体蛋白S6（p-S6，哺乳动物雷帕霉素靶蛋白（mTOR）激活的替代标志物）和p21在125例口腔鳞状细胞癌（OSCC）患者中的临床相关性。
方法
进行免疫组织化学分析以确定p-S6在Ser235/236和Ser240/244位点的磷酸化状态、p21以及p53蛋白表达。
结果
分别在83%和88%的肿瘤中检测到磷酸化S6蛋白在丝氨酸235/236或丝氨酸240/244位点的表达，二者均与肿瘤大小和局部浸润呈显著负相关。91.5%的病例中p21表达呈阳性，且与肿瘤大小呈负相关。在OSCC中，p21表达与mTOR激活的替代标志物p-S6水平相关，与p53状态无关。
结论
在OSCC患者中，p21和p-S6的表达均与肿瘤大小呈负相关，但与生存结果无关。
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