[各种神经系统疾病患者脑脊液中某些酶活性的变化]

[Changes in some cerebrospinal fluid enzyme activities in patients with various neurological diseases].

作者信息

Savoia M R, De Vita N, Svelto S, Ferro V

出版信息

Quad Sclavo Diagn. 1985 Jun;21(2):163-72.

Abstract

The authors have examined the activities of the enzymes GOT, CPT, CK, LDH, gamma-GT, PCHE and ALP in the cerebrospinal fluid of 50 patients with various neurological diseases. The results obtained show that many activities constantly and remarkably increase in few diseases of the nervous system. Particularly, GOT, GPT, LDH and ALP demonstrated raised values in the meningitis; LDH, CK, GOT, GPT in the brain tumors; CK and LDH in the hydrocephalus. A comparison between the results of the protein and enzyme determinations in the cerebrospinal fluid of the same patients, revealed in the enzymologic reactions a more precocious and sensitive indicator of initial brain lesions.

摘要

作者检测了50例患有各种神经系统疾病患者脑脊液中谷草转氨酶（GOT）、肉碱棕榈酰转移酶（CPT）、肌酸激酶（CK）、乳酸脱氢酶（LDH）、γ-谷氨酰转移酶（γ-GT）、血浆胆碱酯酶（PCHE）和碱性磷酸酶（ALP）的活性。所得结果表明，在少数神经系统疾病中，许多酶的活性持续且显著升高。特别是，脑膜炎患者的GOT、谷丙转氨酶（GPT）、LDH和ALP值升高；脑肿瘤患者的LDH、CK、GOT、GPT升高；脑积水患者的CK和LDH升高。对同一患者脑脊液中蛋白质和酶检测结果的比较显示，酶学反应是初始脑损伤更早期和敏感的指标。