Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, PR China.
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, PR China.
Biomaterials. 2017 Oct;141:116-124. doi: 10.1016/j.biomaterials.2017.06.030. Epub 2017 Jun 27.
The heterogeneously-distributed hyperthermia in nanomaterial-mediated photothermal therapy commonly results in incomplete tumor eradication and serious damage of health tissue. Here, we found autophagy was activated in cancer cells underwent photothermal therapy and the inhibition of autophagy significantly enhanced the efficacy of photothermal killing of cancer cells. A formulation of chloroquine-loaded polydopamine nanoparticles was developed for sensitized photothermal cancer therapy, and the in vitro and in vivo study demonstrated that inhibition of autophagy remarkably augmented the efficacy of photothermal therapy, leading to efficient tumor suppression at a mild temperature. The regulation of autophagy provides a new route to increase the efficacy of photothermal cancer therapy.
纳米材料介导的光热治疗中不均匀分布的高热通常导致肿瘤不完全清除和健康组织的严重损伤。在这里，我们发现经历光热治疗的癌细胞中自噬被激活，而自噬的抑制显著增强了光热杀死癌细胞的效果。我们开发了一种载有氯喹的聚多巴胺纳米粒子制剂，用于敏化光热癌症治疗，体外和体内研究表明，自噬的抑制显著增强了光热治疗的效果，在温和的温度下有效地抑制了肿瘤。自噬的调节为提高光热癌症治疗的效果提供了新途径。
