静脉注射脂质体包裹的二氯亚甲基二膦酸盐后脾脏中吞噬细胞的清除。边缘区巨噬细胞清除的超微结构特征。
Elimination of phagocytic cells in the spleen after intravenous injection of liposome-encapsulated dichloromethylene diphosphonate. Ultrastructural aspects of elimination of marginal zone macrophages.
作者信息
van Rooijen N, van Nieuwmegen R, Kamperdijk E W
出版信息
Virchows Arch B Cell Pathol Incl Mol Pathol. 1985;49(4):375-83. doi: 10.1007/BF02912114.
PMID:2867636
Abstract
It is shown ultrastructurally that intravenously injected and liposome-entrapped dichloromethylene diphosphonate (DMDP) causes marked damage to marginal zone macrophages in the mouse spleen which finally results in the elimination of these cells. Marginal zone lymphocytes are also affected by this treatment, probably as a result of action of the enzymes released by dying macrophages. Marginal zone macrophages largely disappear, 24 h after i.v. injection, leaving an open-meshed reticulum in which a few viable and necrotic lymphocytes are present. The proposed method to eliminate macrophages for some time may be used to study functional aspects of these cells in vivo.
摘要
超微结构显示，静脉注射并包裹于脂质体中的二氯亚甲基二膦酸盐（DMDP）对小鼠脾脏边缘区巨噬细胞造成显著损伤，最终导致这些细胞被清除。边缘区淋巴细胞也受到这种处理的影响，这可能是垂死巨噬细胞释放的酶作用的结果。静脉注射后24小时，边缘区巨噬细胞大量消失，留下一个开放网孔状的网状结构，其中存在一些存活和坏死的淋巴细胞。这种在一段时间内清除巨噬细胞的方法可用于研究这些细胞在体内的功能方面。
相似文献
1
Elimination of phagocytic cells in the spleen after intravenous injection of liposome-encapsulated dichloromethylene diphosphonate. Ultrastructural aspects of elimination of marginal zone macrophages.静脉注射脂质体包裹的二氯亚甲基二膦酸盐后脾脏中吞噬细胞的清除。边缘区巨噬细胞清除的超微结构特征。
Virchows Arch B Cell Pathol Incl Mol Pathol. 1985;49(4):375-83. doi: 10.1007/BF02912114.
2
Elimination of phagocytic cells in the spleen after intravenous injection of liposome-encapsulated dichloromethylene diphosphonate. An enzyme-histochemical study.静脉注射脂质体包裹的二氯亚甲基二膦酸盐后脾脏中吞噬细胞的清除。一项酶组织化学研究。
Cell Tissue Res. 1984;238(2):355-8. doi: 10.1007/BF00217308.
3
Depletion and repopulation of macrophages in spleen and liver of rat after intravenous treatment with liposome-encapsulated dichloromethylene diphosphonate.经脂质体包裹的二氯亚甲基二膦酸盐静脉注射处理后大鼠脾脏和肝脏中巨噬细胞的耗竭与再填充
Cell Tissue Res. 1990 May;260(2):215-22. doi: 10.1007/BF00318625.
4
In vitro and in vivo elimination of macrophage tumor cells using liposome-encapsulated dichloromethylene diphosphonate.使用脂质体包裹的二氯亚甲基二膦酸盐在体外和体内消除巨噬细胞肿瘤细胞。
Virchows Arch B Cell Pathol Incl Mol Pathol. 1988;54(4):241-5. doi: 10.1007/BF02899217.
5
Characterization of cell populations, reappearing in the mouse spleen after elimination by liposome encapsulated dichloromethylene diphosphonate: reappearance of marginal zone lymphocytes is independent of marginal zone macrophages.脂质体包裹的二氯亚甲基二膦酸盐清除后在小鼠脾脏中再次出现的细胞群体特征：边缘区淋巴细胞的再次出现与边缘区巨噬细胞无关。
Adv Exp Med Biol. 1988;237:889-93. doi: 10.1007/978-1-4684-5535-9_133.
6
Macrophage subset repopulation in the spleen: differential kinetics after liposome-mediated elimination.脾脏中巨噬细胞亚群的再填充：脂质体介导清除后的不同动力学
J Leukoc Biol. 1989 Feb;45(2):97-104. doi: 10.1002/jlb.45.2.97.
7
Effects of intracellular diphosphonates on cells of the mononuclear phagocyte system: in vivo effects of liposome-encapsulated diphosphonates on different macrophage subpopulations in the spleen.细胞内双膦酸盐对单核吞噬细胞系统细胞的影响：脂质体包裹的双膦酸盐对脾脏中不同巨噬细胞亚群的体内影响。
Calcif Tissue Int. 1989 Sep;45(3):153-6. doi: 10.1007/BF02556058.
8
Changes in murine bone marrow macrophages and erythroid burst-forming cells following the intravenous injection of liposome-encapsulated dichloromethylene diphosphonate (Cl2MDP).静脉注射脂质体包裹的二氯亚甲基二膦酸盐（Cl2MDP）后小鼠骨髓巨噬细胞和红细胞爆式形成细胞的变化。
Eur J Haematol. 2001 Apr;66(4):221-9. doi: 10.1034/j.1600-0609.2001.066004221.x.
9
Selective depletion of liver and splenic macrophages using liposomes encapsulating the drug dichloromethylene diphosphonate: effects on antimicrobial resistance.使用包裹二氯亚甲基二膦酸盐药物的脂质体选择性清除肝脏和脾脏巨噬细胞：对抗菌耐药性的影响
J Leukoc Biol. 1991 Jun;49(6):579-86. doi: 10.1002/jlb.49.6.579.
引用本文的文献
1
A Monocytic Barrier to the Humanization of Immunodeficient Mice.单核细胞对免疫缺陷小鼠人源化的屏障。
Curr Stem Cell Res Ther. 2024;19(7):959-980. doi: 10.2174/011574888X263597231001164351.
2
The Role of Macrophages in the Pathogenesis of ALI/ARDS.巨噬细胞在 ALI/ARDS 发病机制中的作用。
Mediators Inflamm. 2018 May 13;2018:1264913. doi: 10.1155/2018/1264913. eCollection 2018.
3
Targeting CD64 mediates elimination of M1 but not M2 macrophages in vitro and in cutaneous inflammation in mice and patient biopsies.靶向CD64可介导在体外以及在小鼠皮肤炎症和患者活检组织中清除M1巨噬细胞，但不能清除M2巨噬细胞。
MAbs. 2015;7(5):853-62. doi: 10.1080/19420862.2015.1066950.
4
Bisphosphonates and cancer: what opportunities from nanotechnology?双膦酸盐与癌症：纳米技术带来了哪些机遇？
J Drug Deliv. 2013;2013:637976. doi: 10.1155/2013/637976. Epub 2013 Mar 4.
5
Mycoplasmal lipopeptide MALP-2 induces the chemoattractant proteins macrophage inflammatory protein 1alpha (MIP-1alpha), monocyte chemoattractant protein 1, and MIP-2 and promotes leukocyte infiltration in mice.支原体脂肽MALP-2可诱导趋化蛋白巨噬细胞炎性蛋白1α（MIP-1α）、单核细胞趋化蛋白1和MIP-2，并促进小鼠白细胞浸润。
Infect Immun. 1999 Jul;67(7):3390-8. doi: 10.1128/IAI.67.7.3390-3398.1999.
6
The role of macrophages in T cell-mediated autoimmune diabetes in nonobese diabetic mice.巨噬细胞在非肥胖糖尿病小鼠T细胞介导的自身免疫性糖尿病中的作用。
J Exp Med. 1999 Jan 18;189(2):347-58. doi: 10.1084/jem.189.2.347.
7
Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ.通过预先清除靶器官中的组织巨噬细胞增强体内腺病毒介导的基因转移和表达。
J Virol. 1997 Jan;71(1):624-9. doi: 10.1128/JVI.71.1.624-629.1997.
8
West Nile virus neuroinvasion and encephalitis induced by macrophage depletion in mice.巨噬细胞耗竭诱导小鼠西尼罗河病毒神经侵袭和脑炎
Arch Virol. 1996;141(3-4):459-69. doi: 10.1007/BF01718310.
9
Reversible depletion of synovial lining cells after intra-articular treatment with liposome-encapsulated dichloromethylene diphosphonate.关节腔内注射脂质体包裹的二氯亚甲基二膦酸盐后滑膜衬里细胞的可逆性耗竭
Rheumatol Int. 1993;13(1):21-30. doi: 10.1007/BF00290330.
10
The effects of liposome-encapsulated and free clodronate on the growth of macrophage-like cells in vitro: the role of calcium and iron.脂质体包裹的氯膦酸盐与游离氯膦酸盐对体外巨噬细胞样细胞生长的影响：钙和铁的作用
Calcif Tissue Int. 1993 Aug;53(2):139-46. doi: 10.1007/BF01321893.
Zotero 插件