Paraskevopoulou Maria D, Tsichlis Philip N
Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA.
Sci Signal. 2017 Jul 4;10(486):eaan8791. doi: 10.1126/scisignal.aan8791.
Since its discovery more than 25 years ago, the kinase AKT has become a central figure in cell signaling. We highlight some of the landmark findings in those 25 years that contributed to our understanding of the regulation and function of AKT in directing cellular processes and behavior. Future progress toward fully understanding the roles of AKT in cell, tissue, and organismal biology will depend on technological innovations and the combination of in-depth reductionist analyses with systems-based strategies.
自25多年前被发现以来，激酶AKT已成为细胞信号传导中的核心角色。我们着重介绍这25年中的一些具有里程碑意义的发现，这些发现有助于我们理解AKT在指导细胞过程和行为中的调节作用及功能。在全面理解AKT在细胞、组织和生物体生物学中的作用方面，未来的进展将取决于技术创新以及深入的还原论分析与基于系统的策略的结合。
