Peng M, Li S, Wu J, Guo Y, Cao S, Zhao Y
The College of Chemistry and Molecular Engineering, The Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, Zhengzhou University, No. 100 Science Avenue, Zhengzhou, 450001, China.
Zhengzhou Central Hospital Affiliated to Zhengzhou University, No. 195 Tongbai Road, Zhengzhou, 450007, China.
J Mass Spectrom. 2017 Sep;52(9):591-596. doi: 10.1002/jms.3965.
Sartans and related analogues with 5-oxo-l, 2, 4-oxadiazole ring and tetrazole ring are investigated in detail using collision-induced dissociation (CID) method in positive ion mode by electrospray ionization tandem mass spectrometry (ESI-MS ). It is found that the protonated sartans and related analogues tend to form the N-substituted-3-substituted phenanthridin-6-amine ion which has a large conjugative structure. The possible fragmentation pathways were proposed for the first time, and the key structure of product ions was confirmed by high resolution tandem mass spectrometry and theoretical calculation. It is very helpful for understanding the intriguing roles of sartans analogues in fragmentation reactions and enriching the knowledge of the gas-phase chemistry of the oxadiazole and tetrazole ring. Copyright © 2017 John Wiley & Sons, Ltd.
利用电喷雾电离串联质谱（ESI-MS）的正离子模式，采用碰撞诱导解离（CID）方法对含有5-氧代-1,2,4-恶二唑环和四唑环的沙坦类药物及其相关类似物进行了详细研究。研究发现，质子化的沙坦类药物及其相关类似物倾向于形成具有大共轭结构的N-取代-3-取代菲啶-6-胺离子。首次提出了可能的裂解途径，并通过高分辨率串联质谱和理论计算确定了产物离子的关键结构。这对于理解沙坦类类似物在裂解反应中的有趣作用以及丰富恶二唑环和四唑环气相化学的知识非常有帮助。版权所有© 2017约翰威立父子有限公司。
