Iqbal Jahangir, Al Qarni Ali, Hawwari Abbas, Alghanem Ahmad F, Ahmed Gasmelseed
King Abdullah International Medical Research Center, MNGHA, Al Ahsa, 31982, Saudi Arabia.
Curr Diabetes Rev. 2018;14(5):427-433. doi: 10.2174/1573399813666170705161039.
Metabolic syndrome is associated with increased risk for both type 2 diabetes and cardiovascular disease. Development of these pathologies is associated with the disorders of lipid and lipoprotein metabolism. Dyslipidemia leads to the overproduction of potentially atherogenic lipid and lipoproteins. Furthermore, there is a decrease in the levels of high-density lipoproteins and an increase in the levels of remnant and small dense LDL particles.
In the current review, we have discussed the pathophysiology of lipoprotein biosynthesis and metabolism in the metabolic syndrome. Finally, we describe regulation of lipoprotein metabolism which may be used as a potential target for treating dyslipidemia in metabolic syndrome.
代谢综合征与2型糖尿病和心血管疾病的风险增加相关。这些病理状况的发展与脂质和脂蛋白代谢紊乱有关。血脂异常导致潜在致动脉粥样硬化脂质和脂蛋白的过度产生。此外，高密度脂蛋白水平降低，残余和小而密低密度脂蛋白颗粒水平升高。
在当前综述中，我们讨论了代谢综合征中脂蛋白生物合成和代谢的病理生理学。最后，我们描述了脂蛋白代谢的调节，其可作为治疗代谢综合征血脂异常的潜在靶点。
