一种利用异种反应性抗体减轻可卡因诱导行为的生物共轭物。
A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior.
作者信息
Jacob NIcholas T, Anraku Kensaku, Kimishima Atsushi, Zhou Bin, Collins Karen C, Lockner Jonathan W, Ellis Beverley A, Janda Kim D
机构信息
Department of Chemistry, Department of Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, The Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, USA.
出版信息
Chem Commun (Camb). 2017 Jul 18;53(58):8156-8159. doi: 10.1039/c7cc04055e.
Abstract
A method for potentiating the response to an anti-cocaine vaccine by leveraging xenoreactive antibodies against the carbohydrate epitope Galα1,3-Gal (GAL) was found to result in a highly specific anti-cocaine response that was able to significantly attenuate cocaine-induced locomotion at 20 mg kg with superior efficacy compared to a standard conjugate.
摘要
一种通过利用针对碳水化合物表位Galα1,3 - Gal（GAL）的异种反应性抗体来增强抗可卡因疫苗反应的方法，被发现可产生高度特异性的抗可卡因反应，与标准偶联物相比，该反应能够在20毫克/千克剂量下显著减弱可卡因诱导的运动，且具有更高的效力。
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