针对滥用药物的疫苗：是半满还是半空？
Vaccines targeting drugs of abuse: is the glass half-empty or half-full?
机构信息
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC 582, La Jolla, California 92037-1000, USA.
出版信息
Nat Rev Immunol. 2011 Dec 16;12(1):67-72. doi: 10.1038/nri3130.
The advent of vaccines targeting drugs of abuse heralded a fundamentally different approach to treating substance-related disorders. In contrast to traditional pharmacotherapies for drug abuse, vaccines act by sequestering circulating drugs and terminating the drug-induced 'high' without inducing unwanted neuromodulatory effects. Drug-targeting vaccines have entered clinical evaluation, and although these vaccines show promise from a biomedical viewpoint, the ethical and socioeconomic implications of vaccinating patients against drugs of abuse merit discussion within the scientific community.
疫苗针对药物滥用的出现开创了一种治疗物质相关障碍的根本不同的方法。与传统的药物滥用药物治疗相比，疫苗通过隔离循环中的药物并终止药物引起的“快感”而不引起不必要的神经调节作用来起作用。药物靶向疫苗已经进入临床评估，尽管从生物医学的角度来看，这些疫苗显示出了希望，但为滥用药物的患者接种疫苗的伦理和社会经济影响值得在科学界进行讨论。
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