Quanzhou 1st Hospital Affiliated to Fujian Medical University, Chendong Area, 10th floor district N13, Inpatient Department, Quanzhou, 362000, Fujian, China.
Exp Physiol. 2017 Oct 1;102(10):1269-1277. doi: 10.1113/EP086520. Epub 2017 Aug 24.
What is the central question of this study? We investigated the potential neuroprotective effects of catechin after traumatic brain injury and explored the underlying mechanisms. What is the main finding and its importance? Catechin treatment had neuroprotective effects in a rat model of traumatic brain injury, and these effects might be mediated by intervention in the self-perpetuating process of blood-brain barrier disruption and excessive inflammatory reaction. Traumatic brain injury (TBI) resulting from external force on the head usually leads to long-term deficits in motor and cognitive functions. Catechin has shown neuroprotective effects in neurodegenerative diseases and ischaemia models. We therefore investigated the potential neuroprotective effects of catechin after TBI and explored the underlying mechanisms. Male rats were subjected to controlled cortical impact injury and then treated with catechin. Brain damage, motor and cognitive functions, blood-brain barrier (BBB) integrity and neuro-inflammation were examined. Catechin treatment ameliorated brain damage and motor and cognitive deficits after TBI. Catechin was shown to protect BBB integrity, alleviate the TBI-induced loss of the junction proteins occludin and zonula occludens protein-1 and suppress local inflammatory reactions. Catechin treatment had neuroprotective effects in a rat model of TBI, and these effects might be mediated by intervention in the self-perpetuating process of BBB disruption and excessive inflammatory reaction.
这项研究的核心问题是什么？我们调查了儿茶素在创伤性脑损伤后的潜在神经保护作用，并探讨了其潜在机制。主要发现及其重要性是什么？儿茶素治疗对创伤性脑损伤大鼠模型具有神经保护作用，这些作用可能通过干预血脑屏障破坏和过度炎症反应的自我维持过程来介导。头部受到外力导致的创伤性脑损伤（TBI）通常会导致运动和认知功能的长期缺陷。儿茶素在神经退行性疾病和缺血模型中显示出神经保护作用。因此，我们研究了儿茶素在创伤性脑损伤后的潜在神经保护作用，并探讨了其潜在机制。雄性大鼠接受皮质撞击伤，然后用儿茶素治疗。检查脑损伤、运动和认知功能、血脑屏障（BBB）完整性和神经炎症。儿茶素治疗改善了 TBI 后的脑损伤以及运动和认知缺陷。儿茶素可保护 BBB 完整性，减轻 TBI 诱导的紧密连接蛋白 occludin 和闭合蛋白-1 的丢失，并抑制局部炎症反应。儿茶素治疗对创伤性脑损伤大鼠模型具有神经保护作用，这些作用可能通过干预血脑屏障破坏和过度炎症反应的自我维持过程来介导。
