两种含有两种不同席夫碱的新型钴（II）配合物：对人皮肤癌细胞生长的抑制作用
Two novel Co(II) complexes with two different Schiff bases: inhibiting growth of human skin cancer cells.
作者信息
Xiao Y-J, Diao Q-C, Liang Y-H, Zeng K
机构信息
Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Department of Dermatology, The Chongqing Hospital of Traditional Chinese Medicine (The First People's Hospital of Chongqing City), Chongqing, China.
出版信息
Braz J Med Biol Res. 2017 Jul 3;50(7):e6390. doi: 10.1590/1414-431X20176390.
Using two flexible Schiff bases, H2L1 and H2L2, two new cobalt II (Co(II))-coordination compounds, namely, Py3CoL1 (1) and Py3CoL2 (2) (Py=pyridine, L1=3,5-ClC6H2(O)C=NC6H3(O)-4-NO2, L2=3,5-BrC6H2(O)C=NC6H3(O)-4-NO2) have been synthesized under solvothermal conditions. Single crystal X-ray structural analysis revealed that compounds 1 and 2 are both six-coordinate in a distorted octahedral geometry, and the 1D chain structure was formed by the π…π and C-H…O interactions or C-H…Cl interaction. The in vitro antitumor activities of 1, 2 and their corresponding organic ligands Py, L1, and L2 were studied and evaluated, in which three human skin cancer cell lines (A-431, HT-144 and SK-MEL-30) were used in the screening tests.
利用两种柔性席夫碱H2L1和H2L2，在溶剂热条件下合成了两种新型钴（II）（Co（II））配位化合物，即Py3CoL1（1）和Py3CoL2（2）（Py =吡啶，L1 = 3,5 - ClC6H2（O）C = NC6H3（O）- 4 - NO2，L2 = 3,5 - BrC6H2（O）C = NC6H3（O）- 4 - NO2）。单晶X射线结构分析表明，化合物1和2均为六配位，呈扭曲的八面体几何构型，且通过π…π和C - H…O相互作用或C - H…Cl相互作用形成一维链状结构。研究并评估了1、2及其相应有机配体Py、L1和L2的体外抗肿瘤活性，筛选试验中使用了三种人类皮肤癌细胞系（A - 431、HT - 144和SK - MEL - 30）。
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