Proĭnova V A, Golovanova I V, Golubeva M I, Shashkina L F
Farmakol Toksikol. 1985 Nov-Dec;48(6):89-93.
A single administration of dimebon (800 mg/kg) to rats per os (2/3 of the LD50 isoeffective for females) raises the preimplantation death, whereas pipolphen increases the intrauterine lethality and inhibits the development of fetuses. Pipolphen in a dose of 175 mg/kg and dimebon in doses of 300-150 mg/kg (exceeding 25- and 300-150-fold, respectively, the therapeutic dose for man) do not exert any specific embryotropic action.
给大鼠经口单次给予二甲金刚胺（800毫克/千克）（对雌性大鼠为半数致死量等效剂量的2/3）会增加植入前死亡率，而哌泊非嗪会增加子宫内致死率并抑制胎儿发育。剂量为175毫克/千克的哌泊非嗪和剂量为300 - 150毫克/千克的二甲金刚胺（分别超过人类治疗剂量25倍和300 - 150倍）未表现出任何特定的胚胎毒性作用。
