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双氯芬酸抑制27-羟基胆固醇诱导的单核细胞分化为成熟树突状细胞。

Diclofenac Inhibits 27-hydroxycholesterol-induced Differentiation of Monocytic Cells into Mature Dendritic Cells.

作者信息

Son Yonghae, Kim Bo-Young, Park Young Chul, Kim Koanhoi

机构信息

Department of Pharmacology, Pusan National University School of Medicine, Yangsan 50612, Korea.

Institute of Marine BioTechnology, Pusan National University, Busan 46241, Korea.

出版信息

Immune Netw. 2017 Jun;17(3):179-185. doi: 10.4110/in.2017.17.3.179. Epub 2017 Jun 20.

DOI:10.4110/in.2017.17.3.179
PMID:28680379
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5484648/
Abstract

We investigated whether diclofenac could influence the development of antigen-presenting cells in an oxygenated cholesterol-rich environment by determining its effects on the 27-hydroxycholesterol (27OHChol)-induced differentiation of monocytic cells into mature dendritic cells (mDCs). Treatment of human THP-1 monocytic cells with diclofenac antagonized the effects of 27OHChol by attenuating dendrite formation and cell attachment and promoting endocytic function. Diclofenac inhibited the transcription and surface expression of the mDC markers of CD80, CD83, and CD88, and reduced the 27OHChol-induced elevation of surface levels of MHC class I and II molecules to the basal levels in a dose-dependent manner. It also reduced the expression of CD197, a molecule involved in DC homing and migration. These results indicate that diclofenac inhibits the differentiation of monocytic cells into mDCs, thereby potentially modulating adaptive immune responses in a milieu rich in cholesterol oxidation products.

摘要

我们通过测定双氯芬酸对27-羟基胆固醇（27OHChol）诱导的单核细胞分化为成熟树突状细胞（mDCs）的影响，研究了双氯芬酸是否会在富含氧化胆固醇的环境中影响抗原呈递细胞的发育。用双氯芬酸处理人THP-1单核细胞，可通过减弱树突形成和细胞附着以及促进内吞功能来拮抗27OHChol的作用。双氯芬酸抑制CD80、CD83和CD88等mDC标志物的转录和表面表达，并以剂量依赖性方式将27OHChol诱导的MHC I类和II类分子表面水平升高降低至基础水平。它还降低了参与DC归巢和迁移的分子CD197的表达。这些结果表明，双氯芬酸抑制单核细胞向mDCs的分化，从而可能在富含胆固醇氧化产物的环境中调节适应性免疫反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d5b/5484648/447c287f991e/in-17-179-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d5b/5484648/232482d07937/in-17-179-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d5b/5484648/e32f90c177a2/in-17-179-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d5b/5484648/41c1c9480b83/in-17-179-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d5b/5484648/485e13a103e2/in-17-179-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d5b/5484648/447c287f991e/in-17-179-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d5b/5484648/232482d07937/in-17-179-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d5b/5484648/e32f90c177a2/in-17-179-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d5b/5484648/41c1c9480b83/in-17-179-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d5b/5484648/485e13a103e2/in-17-179-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d5b/5484648/447c287f991e/in-17-179-g005.jpg

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Dexamethasone Suppresses Oxysterol-Induced Differentiation of Monocytic Cells.地塞米松抑制氧化甾醇诱导的单核细胞分化。
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瑞布拉他汀在富含27-羟基胆固醇的环境中抑制单核细胞/巨噬细胞的表型变化。
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