Sattar Sidra, Akhunzada Naveed Z, Javed Gohar, Uddin Zeeshan, Khan Yasir A
Community Health Sciences Department, Ziauddin University, Karachi, Pakistan.
Department of Neurosurgery, Aga Khan University Hospital, Karachi, Pakistan.
Surg Neurol Int. 2017 Jun 13;8:116. doi: 10.4103/sni.sni_468_16. eCollection 2017.
Pilocytic astrocytoma (PA) is the most prevalent central nervous system (CNS) tumor in pediatric population and accounts for an approximate of 5-6% of all gliomas. This neoplasm can occur at all levels of the neuraxis, with majority (67%) arising in the cerebellum and optic pathway. PAs are World Health Organization Grade I tumors and are the most benign of all astrocytomas characterized by an excellent prognosis. Other differentials include subependymal giant cell astrocytoma (SEGA), ependymoma, meningioma, and low-grade gliomas such as pilocytic or diffuse astrocytoma; calcification is more commonly regarded as a feature of benign or slow-growing tumors.
We present a case of a 17-year-old female presenting with an unusual cause of hydrocephalus, a rare case of a calcified pilocytic astrocytoma as an intraventricular tumor.
PA rarely presents as an intraventricular tumor and should be included in the differential diagnosis of a large mass with massive intratumoral calcification.
毛细胞型星形细胞瘤（PA）是儿童人群中最常见的中枢神经系统（CNS）肿瘤，约占所有胶质瘤的5 - 6%。这种肿瘤可发生于神经轴的各个水平，大多数（67%）起源于小脑和视路。PA是世界卫生组织一级肿瘤，是所有星形细胞瘤中最良性的，预后极佳。其他鉴别诊断包括室管膜下巨细胞星形细胞瘤（SEGA）、室管膜瘤、脑膜瘤以及低级别胶质瘤，如毛细胞型或弥漫性星形细胞瘤；钙化更常被视为良性或生长缓慢肿瘤的特征。
我们报告一例17岁女性患者，其因一种不寻常的原因导致脑积水，这是一例罕见的钙化毛细胞型星形细胞瘤作为脑室内肿瘤的病例。
PA很少表现为脑室内肿瘤，在鉴别诊断伴有大量肿瘤内钙化的大肿块时应考虑到。
