Hadizadeh S, Forootanfar H, Shahidi Bonjar G H, Falahati Nejad M, Karamy Robati A, Ayatollahi Mousavi S A, Amirporrostami S
Department of Medical Mycology & Parasitology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Curr Med Mycol. 2015 Jun;1(2):19-24. doi: 10.18869/acadpub.cmm.1.2.19.
Actinomycetes have been discovered as source of antifungal compounds that are currently in clinical use. Invasive aspergillosis (IA) due to has been identified as individual drug-resistant to be an emerging pathogen opportunities a global scale. This paper described the antifungal activity of one terrestrial actinomycete against the clinically isolated azole-resistant .
Soil samples were collected from various locations of Kerman, Iran. Thereafter, the actinomycetes were isolated using starch-casein-nitrate-agar medium and the most efficient actinomycetes (capable of inhibiting ) were screened using agar block method. In the next step, the selected actinomycete was cultivated in starch-casein- broth medium and the inhibitory activity of the obtained culture broth was evaluated using agar well diffusion method.
The selected actinomycete, identified as strain HF391, could suppress the growth of isolates which was isolated from the clinical samples of patients treated with azoles. This strain showed higher inhibition zones on agar diffusion assay which was more than 15 mm.
The obtained results of the present study introduced strain HF391 as terrestrial actinomycete that can inhibit the growth of clinically isolated
放线菌已被发现是目前临床使用的抗真菌化合物的来源。由已被确定为对个别药物耐药的新兴病原体引起的侵袭性曲霉病（IA）在全球范围内构成威胁。本文描述了一种陆生放线菌对临床分离的唑类耐药菌的抗真菌活性。
从伊朗克尔曼的不同地点采集土壤样本。此后，使用淀粉 - 酪蛋白 - 硝酸盐 - 琼脂培养基分离放线菌，并使用琼脂块法筛选出最有效的放线菌（能够抑制……）。下一步，将所选放线菌在淀粉 - 酪蛋白肉汤培养基中培养，并使用琼脂孔扩散法评估所得培养液的抑制活性。
所选放线菌被鉴定为链霉菌属菌株HF391，它能够抑制从接受唑类治疗的患者临床样本中分离出的……菌株的生长。该菌株在琼脂扩散试验中显示出大于15毫米的更高抑菌圈。
本研究获得的结果表明链霉菌属菌株HF391是一种能够抑制临床分离菌生长的陆生放线菌
