Bangudu A B, Pilpel N
J Pharm Pharmacol. 1985 Dec;37(12):903-5. doi: 10.1111/j.2042-7158.1985.tb04998.x.
The effects of separately varying the packing fraction (P), the proportions of microcrystalline cellulose, Avicel (A) and alginic acid, disintegrant (D), on both the tensile strengths and disintegration times of paracetamol tablets are in the order P much greater than A much greater than D. The combined effects of these variables on both tensile strength and disintegration time are A X P much greater than D X P greater than A X D.
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