Esezobo S, Zubair S, Pilpel N
Department of Pharmaceutics & Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Nigeria.
J Pharm Pharmacol. 1989 Jan;41(1):7-10. doi: 10.1111/j.2042-7158.1989.tb06319.x.
The properties of tapioca obtained from cassava (Manihot utilissima) have been evaluated. Its binding effect in tablets of paracetamol on the disintegration and dissolution rates was compared with tablets prepared with polyvinylpyrrolidone and gelatin. The nature and amount of the binders were found to alter the disintegration and dissolution rates of the tablets by reducing their wettability as measured by the adhesion tension of water. A linear relationship has been found to exist between the adhesion of water on the tablets and their disintegration and dissolution rates.
对从木薯（木薯属）中提取的木薯淀粉的特性进行了评估。将其在对乙酰氨基酚片剂中的黏合作用对崩解和溶解速率的影响，与用聚乙烯吡咯烷酮和明胶制备的片剂进行了比较。发现黏合剂的性质和用量会通过降低水的附着力所测量的润湿性来改变片剂的崩解和溶解速率。已发现水在片剂上的附着力与其崩解和溶解速率之间存在线性关系。
