铜催化炔烃的亚胺乙烯基化反应通过 1,3-乙烯基迁移。
Copper-Catalyzed Imidovinylation of Alkynes via 1,3-Vinyl Migration.
机构信息
Key Laboratory of Functional Organic Molecule Design & Synthesis of Jilin Province, Department of Chemistry, Northeast Normal University , Changchun 130024, China.
出版信息
Org Lett. 2017 Jul 21;19(14):3767-3770. doi: 10.1021/acs.orglett.7b01599. Epub 2017 Jul 6.
PMID:28682081
Abstract
The first copper-catalyzed imidovinylation of alkynes has been developed, which grants facile access to various (E)-2-imido-2,4-dienals with high stereoselectivity under mild conditions. This transformation also represents the first 1,3-carbon migration of propargylic alcohols and their derivatives.
摘要
发展了首例铜催化的炔烃亚胺乙烯基化反应，该反应在温和条件下以高立体选择性地获得了各种（E）-2-亚胺-2,4-二烯醛。该转化也代表了丙炔醇及其衍生物的首例 1,3-碳迁移。
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