Langenmair Elia Raoul, Konstantinidis Lukas, Südkamp Norbert P, Helwig Peter
Klinik für Orthopädie und Unfallchirurgie, Universitätsklinik Freiburg.
Z Orthop Unfall. 2017 Jun;155(3):310-317. doi: 10.1055/s-0043-100098. Epub 2017 Jul 6.
Prosthetic hip joint infection is a common severe complication with a high socio-economic impact. The inconsistency of the available data and the absence of binding guidelines lead to a variety of diagnostic and therapeutic strategies. The aim of this study is to present the current diagnostic and therapeutic approach to treating infections after total hip arthroplasties in German hospitals, link it with current evidence, and evaluate the willingness of these hospitals to participate in prospective multicentre trials. An online questionnaire for digital processing was sent to hospitals performing joint replacement procedures. These institutions included district hospitals, private hospitals, non-university maximum care facilities, statutory accident insurance hospitals, and university hospitals. A total of 107 hospitals took part in the survey, corresponding to a response rate of 27.6%. These hospitals perform approximately 2,951 revisions of infected total hip arthroplasties per year. Two-stage revision arthroplasty is the preferred procedure after prosthetic hip infections. The algorithm proposed by Zimmerli et al. is widely recognised. There is a lack of uniformity in the key features for revision of prosthetic joint infections - long vs. short interval in case of two-stage revision, duration of intravenous and oral administration of antibiotics, cemented vs. cement-free implant procedures, and follow-up intervals after revision surgery. The willingness to participate in clinical trials is high. The controversial data leads to multiple treatment approaches. The high willingness to participate in adequately funded clinical trials offers a potential for multicentre trials to be conducted. There is an urgent need for funding to make this research possible.
人工髋关节感染是一种常见的严重并发症,具有很高的社会经济影响。现有数据的不一致以及缺乏具有约束力的指南导致了多种诊断和治疗策略。本研究的目的是介绍德国医院目前治疗全髋关节置换术后感染的诊断和治疗方法,将其与当前证据联系起来,并评估这些医院参与前瞻性多中心试验的意愿。向进行关节置换手术的医院发送了一份用于数字处理的在线问卷。这些机构包括地区医院、私立医院、非大学型特级护理机构、法定事故保险医院和大学医院。共有107家医院参与了调查,回复率为27.6%。这些医院每年大约进行2951例感染性全髋关节置换翻修手术。两阶段翻修置换术是人工髋关节感染后的首选手术方法。齐默利等人提出的算法得到了广泛认可。在人工关节感染翻修的关键特征方面缺乏一致性——两阶段翻修时的间隔时间长短、抗生素静脉和口服给药的持续时间、骨水泥型与非骨水泥型植入手术以及翻修手术后的随访间隔。参与临床试验的意愿很高。有争议的数据导致了多种治疗方法。参与资金充足的临床试验意愿很高,这为开展多中心试验提供了可能性。迫切需要资金来使这项研究成为可能。