Scala Marcello, Morana Giovanni, Milanaccio Claudia, Pavanello Marco, Nozza Paolo, Garrè Maria Luisa
Neuro-Oncology Unit.
Neuroradiology Unit, and.
J Neurosurg Pediatr. 2017 Sep;20(3):284-288. doi: 10.3171/2017.2.PEDS16526. Epub 2017 Jul 7.
Atypical choroid plexus papillomas can metastasize in the form of leptomeningeal seeding. Postoperative chemotherapy is the recommended first-line treatment when gross-total removal is not achieved or in cases of disseminated disease. Here the authors report on 2 children with atypical choroid plexus papillomas and MRI findings of diffuse leptomeningeal enhancement at diagnosis, later presenting with spontaneous resolution of the leptomeningeal involvement after removal of the primary lesions. Observations in this report expand our knowledge about the natural history and biological behavior of these tumors and highlight the role of close neuroimaging surveillance in the management of atypical choroid plexus papillomas in cases with MRI evidence of diffuse leptomeningeal enhancement at presentation.
非典型脉络丛乳头状瘤可呈软脑膜播散形式转移。当无法实现全切或存在播散性疾病时，术后化疗是推荐的一线治疗方法。在此，作者报告了2例非典型脉络丛乳头状瘤患儿，诊断时MRI显示弥漫性软脑膜强化，在切除原发病变后，软脑膜受累自发消退。本报告中的观察结果扩展了我们对这些肿瘤自然史和生物学行为的认识，并强调了在呈现MRI证据显示弥漫性软脑膜强化的非典型脉络丛乳头状瘤病例管理中，密切神经影像学监测的作用。
