Kirchner Henriette, Shaheen Fozia, Kalscheuer Hannes, Schmid Sebastian M, Oster Henrik, Lehnert Hendrik
First Department of Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany.
Stratlab Ltd., March, Cambridgeshire PE15 8QD, UK.
Genes (Basel). 2017 Jul 7;8(7):176. doi: 10.3390/genes8070176.
The attrition of telomeres is believed to be a key event not only in mammalian aging, but also in disturbed nutrient sensing, which could lead to numerous metabolic dysfunctions. The current debate focuses mainly on the question whether telomere shortening, e.g., as a heritable trait, may act as a cause or rather represents a consequence of such chronic diseases. This review discusses the damaging events that ultimately may lead or contribute to telomere shortening and can be associated with metabolic diseases.
端粒磨损不仅被认为是哺乳动物衰老过程中的关键事件，也是营养感知紊乱的关键事件，而营养感知紊乱可能导致多种代谢功能障碍。目前的争论主要集中在端粒缩短（例如作为一种遗传特征）是否可能是这些慢性疾病的病因，还是仅仅是这些慢性疾病的一个后果。这篇综述讨论了最终可能导致或促成端粒缩短并可能与代谢疾病相关的损害性事件。
