Reddy T Srinivasa, Privér Steven H, Mirzadeh Nedaossadat, Bhargava Suresh K
Centre for Advanced Materials & Industrial Chemistry (CAMIC), School of Applied Sciences, RMIT University, GPO BOX 2476, Melbourne 3001, Australia.
Centre for Advanced Materials & Industrial Chemistry (CAMIC), School of Applied Sciences, RMIT University, GPO BOX 2476, Melbourne 3001, Australia.
J Inorg Biochem. 2017 Oct;175:1-8. doi: 10.1016/j.jinorgbio.2017.06.010. Epub 2017 Jun 28.
We report the application of cationic tri- and tetra-nuclear gold(I) phosphine complexes [Au(μ-dppen)]X and [Au(μ-dppa)]X (X=OTf, PF) [OTf=trifluoromethanesulfonate, dppen=trans-1,2-bis(diphenylphosphino)ethene, dppa=bis(diphenylphosphino)acetylene] for cancer treatment. The results of cytotoxicity tests on four different cancer cells [prostate (DU145), cervical (HeLa), breast (MDAMB-231) and fibro sarcoma (HT1080)] indicate these complexes possess remarkable tumor cell growth inhibitory effects and high selectivity towards cancer cells. The anti-tumor mechanism of the tri- and tetra-nuclear gold(I) complexes has also been investigated.
我们报道了阳离子三核和四核金（I）膦配合物[Au(μ-dppen)]X和[Au(μ-dppa)]X（X = OTf、PF）[OTf = 三氟甲磺酸盐，dppen = 反式-1,2-双（二苯基膦基）乙烯，dppa = 双（二苯基膦基）乙炔]在癌症治疗中的应用。对四种不同癌细胞[前列腺癌（DU145）、宫颈癌（HeLa）、乳腺癌（MDAMB-231）和成纤维肉瘤（HT1080）]的细胞毒性测试结果表明，这些配合物具有显著的肿瘤细胞生长抑制作用以及对癌细胞的高选择性。同时也研究了三核和四核金（I）配合物的抗肿瘤机制。
