维生素 E 对暴露于 ZnONP 的尼罗罗非鱼的保护作用。
The protective role of vitamin E on Oreochromis niloticus exposed to ZnONP.
机构信息
Young Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
Federal University of Paraná (UFPR) Laboratory of Cellular Toxicology, Department of Cellular Biology, Paraná, Brasil.
出版信息
Ecotoxicol Environ Saf. 2017 Nov;145:1-7. doi: 10.1016/j.ecoenv.2017.07.005. Epub 2017 Jul 6.
The present study evaluated if ZnONPs induce oxidative stress, immunological impairment and cellular damage in tilapia (Oreochromis niloticus), as well as the possible protective effect of vitamin E. Fish were fed for ten days and five study groups were investigated: controls, two ZnONPs concentrations (1.5 and 2.5mgL) and 1.5 and 2.5mgL of ZnONPs + vitamin E (500mgkg of food). O. niloticus treated with ZnONPs, showed decreased health in comparison with the control group and the groups that combined nanoparticles and vitamin E-supplemented diet. ZnONPs caused cell impairment by increasing ALT, AST and ALP activity and generated oxidative stress by inhibiting SOD and CAT activity. Biochemical changes of these biomarkers were prevented by vitamin E, although this compound did not confer complete protection. In conclusion, ZnONPs are toxic to O. niloticus, affecting antioxidant defenses, with vitamin E acting protectively against this toxic effect.
本研究评估了 ZnO 纳米粒子是否会引起罗非鱼（Oreochromis niloticus）的氧化应激、免疫损伤和细胞损伤，以及维生素 E 的可能保护作用。鱼被喂食了十天，研究了五个实验组：对照组、两种 ZnO 纳米粒子浓度（1.5 和 2.5mg/L）以及 1.5 和 2.5mg/L 的 ZnO 纳米粒子+维生素 E（食物中 500mg/kg）。与对照组和添加纳米粒子和维生素 E 饮食的组相比，用 ZnO 纳米粒子处理的罗非鱼的健康状况下降。ZnO 纳米粒子通过增加 ALT、AST 和 ALP 活性引起细胞损伤，并通过抑制 SOD 和 CAT 活性产生氧化应激。这些生物标志物的生化变化被维生素 E 阻止，尽管这种化合物没有提供完全的保护。总之，ZnO 纳米粒子对罗非鱼有毒，影响抗氧化防御，维生素 E 对这种毒性作用具有保护作用。
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