对扫描未显示多巴胺能缺陷证据（SWEDDs）的患者进行间碘苄胍（MIBG）心肌闪烁显像。
I-Meta-iodobenzylguanidine (MIBG) myocardial scintigraphy in patients showing scans without evidence of dopaminergic deficits (SWEDDs).
作者信息
Yoshii Fumihito, Moriya Yusuke, Ohnuki Tomohide, Ryo Masafuchi, Takahashi Wakoh, Kohara Saori, Hashimoto Jun
机构信息
Department of Neurology, Saiseikai Hiratsuka Hospital, 37-1 Tateno-cho, Hiratsuka, 254-0046, Japan; Department of Neurology, Tokai University Oiso Hospital, 21-1 Gakkyou, Oiso, Naka-gun, 259-0198, Japan.
Department of Neurology, Tokai University Oiso Hospital, 21-1 Gakkyou, Oiso, Naka-gun, 259-0198, Japan.
出版信息
Clin Neurol Neurosurg. 2017 Sep;160:73-77. doi: 10.1016/j.clineuro.2017.06.017. Epub 2017 Jun 27.
OBJECTIVE
Scans without evidence of dopaminergic deficits (SWEDDs) in dopamine transporter single-photon emission computed tomography (DAT-SPECT) are found in 3.6-19.6% of patients with clinically suspected Parkinson's disease (PD). We investigated whether combined use of I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy would be helpful to differentiate PD among SWEDDs patients.
PATIENTS AND METHODS
145 patients with clinically suspected PD underwent both DAT-SPECT and MIBG myocardial scintigraphy. Striatal binding ratio (SBR) of DAT-SPECT and heart-to-mediastinal (H/M) ratio and washout rate (WR) of MIBG myocardial scintigraphy were calculated.
RESULTS
Among 18 SWEDDs patients (12.4%), 11 were finally diagnosed with PD based on follow-up for at least two years after the DAT-SPECT and MIGB myocardial scintigraphy scans. Among the latter group, 8 patients showed an H/M ratio of less than 2.2, and 9 showed WR above 30%.
CONCLUSION
Our results indicate that the combination of low H/M ratio and high WR of MIBG myocardial scintigraphy of SWEDDs patients may be helpful for detection of PD patients.
目的
在临床疑似帕金森病（PD）患者中，多巴胺转运体单光子发射计算机断层扫描（DAT-SPECT）显示无多巴胺能缺陷证据的扫描结果（SWEDDs）占3.6%-19.6%。我们研究了联合使用1-间碘苄胍（MIBG）心肌闪烁显像是否有助于在SWEDDs患者中鉴别PD。
患者与方法
145例临床疑似PD患者接受了DAT-SPECT和MIBG心肌闪烁显像检查。计算DAT-SPECT的纹状体结合率（SBR）以及MIBG心肌闪烁显像的心脏与纵隔（H/M）比值和洗脱率（WR）。
结果
在18例SWEDDs患者（12.4%）中，11例在DAT-SPECT和MIGB心肌闪烁显像扫描后至少随访两年，最终被诊断为PD。在后一组中，8例患者的H/M比值小于2.2，9例患者的WR高于30%。
结论
我们的结果表明，SWEDDs患者MIBG心肌闪烁显像的低H/M比值和高WR相结合可能有助于检测出PD患者。
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