van Marle J, Piek T, Lind A, van Weeren-Kramer J
Experientia. 1986 Feb 15;42(2):157-8. doi: 10.1007/BF01952444.
Two components of the venom of the predatory wasp Philanthus triangulum F. significantly reduce--to a greater or less extent--the high affinity uptake of glutamate in rat hippocampus. A concentration of 10 microM delta-PTX caused a reduction of 74%, while the other component, beta-PTX, at the same concentration, caused a reduction of 18%. Hence the effect of delta-PTX on high affinity glutamate uptake in the hippocampus is comparable with its effect on high affinity glutamate uptake in insect neuromuscular junctions. Contrary to our previous findings that beta-PTX has no effect on high affinity glutamate uptake in insect glutamatergic terminal axons, however, beta-PTX significantly reduces high affinity glutamate uptake in the hippocampus, albeit less effectively than delta-PTX.
捕食性黄蜂三角大头泥蜂毒液的两种成分在不同程度上显著降低了大鼠海马体中谷氨酸的高亲和力摄取。10微摩尔的δ-蜂毒素浓度导致摄取量降低了74%，而另一种成分β-蜂毒素在相同浓度下使摄取量降低了18%。因此，δ-蜂毒素对海马体中高亲和力谷氨酸摄取的影响与其对昆虫神经肌肉接头处高亲和力谷氨酸摄取的影响相当。然而，与我们之前发现β-蜂毒素对昆虫谷氨酸能终末轴突中高亲和力谷氨酸摄取无影响相反，β-蜂毒素显著降低了海马体中高亲和力谷氨酸的摄取，尽管其效果不如δ-蜂毒素。
