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动物毒液作为潜在的抗惊厥药物来源。

Animal Venoms as Potential Source of Anticonvulsants.

机构信息

Monash University Malaysia, Jeffrey Cheah School of Medicine and Health Sciences, Monash University, Bandar Sunway, Selangor, 47500, Malaysia.

School of Dentistry and Medical Sciences, Charles Sturt University, Orange, New South Wales, 2800, Australia.

出版信息

F1000Res. 2024 Mar 27;13:225. doi: 10.12688/f1000research.147027.1. eCollection 2024.

Abstract

Epilepsy affects millions of people worldwide, and there is an urgent need to develop safe and effective therapeutic agents. Animal venoms contain diverse bioactive compounds like proteins, peptides, and small molecules, which may possess medicinal properties against epilepsy. In recent years, research has shown that venoms from various organisms such as spiders, ants, bees, wasps, and conus snails have anticonvulsant and antiepileptic effects by targeting specific receptors and ion channels. This review underscores the significance of purified proteins and toxins from these sources as potential therapeutic agents for epilepsy. In conclusion, this review emphasizes the valuable role of animal venoms as a natural resource for further exploration in epilepsy treatment research.

摘要

癫痫影响着全球数百万人,因此急需开发安全有效的治疗药物。动物毒液中含有多种生物活性化合物,如蛋白质、肽和小分子,它们可能具有抗癫痫的药用特性。近年来的研究表明,来自蜘蛛、蚂蚁、蜜蜂、黄蜂和芋螺等各种生物体的毒液通过靶向特定的受体和离子通道具有抗惊厥和抗癫痫作用。本综述强调了这些来源的纯化蛋白和毒素作为癫痫潜在治疗药物的重要性。总之,本综述强调了动物毒液作为进一步探索癫痫治疗研究的天然资源的宝贵作用。

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本文引用的文献

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