Thakur Jagdeep S, Mahajan Aditi, Saluja Manika, Mohindroo Narinder K
1 Assistant Professor, Department of Otolaryngology-Head and Neck Surgery (ENT), Indira Gandhi Medical College, Shimla, HP, India.
2 Resident, Department of Otolaryngology-Head and Neck Surgery (ENT), Indira Gandhi Medical College, Shimla, HP, India.
Trop Doct. 2017 Jul;47(3):268-271. doi: 10.1177/0049475516684088. Epub 2016 Dec 20.
Nasal NK/T cell lymphoma is rare and it easily masquerades as chronic rhinosinusitis. It has a very poor prognosis and hence early diagnosis, although difficult, is necessary for better outcome. We present a case of a 30-year-old man who presented with nasal obstruction, facial oedema and crusts. High-resolution computed tomography found soft tissue in all sinuses and the nasal cavity. Endoscopic biopsy revealed necrotic and inflammatory tissue with fungi on culture. A diagnosis of fungal rhinosinusitis was made but the patient did not respond to antifungal drugs. A histopathology review with immunohistochemistry suggested nasal NK/T cell lymphoma. The patient was started on chemotherapy but died within 1 week.
鼻NK/T细胞淋巴瘤较为罕见，且容易伪装成慢性鼻-鼻窦炎。其预后极差，因此尽管早期诊断困难，但为了获得更好的治疗结果，早期诊断是必要的。我们报告一例30岁男性患者，其表现为鼻塞、面部水肿和鼻痂。高分辨率计算机断层扫描发现所有鼻窦和鼻腔均有软组织。内镜活检显示坏死和炎性组织，培养发现真菌。诊断为真菌性鼻-鼻窦炎，但患者对抗真菌药物无反应。经免疫组织化学进行的组织病理学复查提示为鼻NK/T细胞淋巴瘤。患者开始接受化疗，但在1周内死亡。
